The role of the vitamin D pathway in airway innate immunity of chronic obstructive pulmonary disease. KU Leuven
This project aims to unravel the role of vitD signaling in the innate immunity of COPD, particularly NF- B driven inflammation and macrophage function. More specifically, we will assess in a smoking mouse model whether vitD signaling is impaired in smoke-exposed lungs, whether smoke-induced changes in vitD signaling correlate with COPD progression, NF- B inflammation and macrophage dysfunction, and whether vitD receptor ablation and/or severe ...