Projects
AN INTEGRAL TECHNOLOGY FOR THE SPECTROSCOPIC IN-SITU ANALYSIS OF THE MOLECULAR RESPONSE OF BIOLOGIC MATERIAL ON ULTRASONIC EXCITATION KU Leuven
Structural, molecular, and cellular biology of PKD2 allosteric modulators as novel therapeutics for cancer KU Leuven
Recently, we applied computer aided drug design to develop
allosteric, isoenzyme specific inhibitors of Protein Kinase D2 (PKD2).
We have now validated our compounds as truly PKD2 isoenzyme
specific, with promising properties against pancreatic cancer,
glioblastoma and multiple myeloma (cancers of high unmet medical
need). While we have designed the compounds to bind a specific
location in PKD2, the crystal ...
Pre-allocated professorship in biomedical molecular biology Ghent University
A position as pre-allocated professor grants one the privilege for a period of maximum 5 years to focus primarily on research, with a teaching load limited to no more than 8 ECTS credits per semester on average over a period of 3 years.
Molecular biology of tyrosyl-tRNA synthetase (YARS) mutations associated with peripheral neuropathy. University of Antwerp
Purchase steam autoclave central kitchen Department of Biomedical Molecular Biology Ghent University
This application for basic equipment concerns funding for a steam autoclave for the central kitchen of our department. This is a really basic instrument crucial for the general functioning of any biochemical-biomedical laboratory. The machine will be used for autoclaving liquids (and glass work) for the research groups of the departments WE14, WE10, WE02 and GE01 working in our building.
Molecular biology of the steroid receptors KU Leuven
The androgen and glucocorticoid receptors (AR and GR) are similar, even when the hormones have very different physiological functions. Both receptors are important clinical targets. Structural and functional information from one receptor can be transferred to the other. We have new data on AR dimerization at the level of the DNA binding domain and the ligand binding domain, which now can be transferred to the GR. Conversely, we have data on ...
Special Research Fund Professorship in molecular cell biology Ghent University
A BOF-ZAP-mandate holder receives an appointment or appointment as a member of the Independent Academic Personnel with mainly research assignment. The wage costs are charged to the resources of the BOF.
Connecting the molecular structure and function of P4/P5B transport ATPases to neuronal cell biology KU Leuven
Research in the Laboratory of Cellular Transport Systems (Department of Cellular and Molecular Medicine; KU Leuven) focuses on P-type transport ATPases in mammalian organism including their role in human neurodegenerative diseases such as Parkinson’s disease. P-type ATPases are transport proteins that generate vital ion or lipid gradients across the plasma membrane or organellar membranes of nearly every cell in the organism. Our current ...