MiR-128 is a novel PHF6 targeting regulatory non-coding RNA acting as a T-ALL oncogene Ghent University
T-cell acute lymphoblastic leukemia (T-ALL) arises through accumulation and interaction between multiple genetic events that perturb normal T-cell differentiation and drive the cellular hallmarks of oncogenesis. Through our previous work, we identified the plant homeodomain finger (PHF6) gene as a novel bona fide tumor suppressor gene in T-ALL (Van Vlierberghe et al. Nature Genetics 2010) and uncovered a mechanism of convergent multi-miRNA ...