Projects
Development of a structural database for improved rational kinase drug design. KU Leuven
Analysis of the TOR kinase complex in organ growth of corn through functional interactomics. Ghent University
Cell proliferation and cell growth are two central aspects of organ growth in every living organism and largely depend on environmental conditions and nutrient availability. The genetic control of these processes determine final organ size and have to be tightly regulated. One of the major regulatory pathways involved in organ growth is controlled by the Target of Rapamycin (TOR) kinase, which translates environmental and nutritional ...
Identification of ferroptosis dependent Tau kinase activity in two in vitro models of Alzheimer's disease. University of Antwerp
Regulation of root hair development by the plant hormone auxin through the receptor-like kinase ERULUS and modulation of cell wall enzyme activity. University of Antwerp
TREATMENT OF GLYCATED TISSUES BY FRUCTOSAMINE-3 KINASE INJECTION Ghent University
Cataract is the major cause of blindness worldwide, and it largely results from age and diabetes. Cataract is also one of the major complications of diabetes mellitus on the eye and up to 20% of all cataract procedures are performed for diabetic patients.
Current standard treatment of cataract is based on surgery (the replacement of the eye lens by a plastic lens). This current surgical treatment (phacoemulsification) is ...
Optimization of the use of tyrosine kinase receptor inhibitors in the preoperative treatment for rectal cancer. KU Leuven
Identification of optimized Aurora Kinase A PROTACs with suitable PK properties for in vivo proof-of-concept studies (OPTIMAPK). Ghent University
Proteolysis targeting chimeras (PROTACs) are small molecule drugs able to selectively remove a disease-causing protein from cells and have emerged as a game-changing technology in drug discovery. We used this technology to induce the removal of Aurora Kinase A, a protein with crucial tumour growth-inducing functions in cancers such as leukemia, prostate cancer and neuroblastoma. We were able to identify a state-of-the-art PROTAC with very ...
Local Rho kinase inhibition in murine colitis: mode of action Ghent University
Rho kinase (ROCK) inhibition is a possible new target in the treatment of inflammatory bowel diseases (IBD). It is a pleiotropic kinase that plays an important role in inflammation and gut homeostasis and it is overproduced in IBD. This researchproject investigates the effects and molecular mechanisms of locally administrated ROCK inhibitors in murine colitis.