Reconstruction of dynamic initiation and progression gene expression regulatorynetworks in neuroblastoma Ghent University
Neuroblastoma (NB) is a lethal tumor of childhood for which therapy has improved little over the past decades and which is assumed to benefit from insights into perturbed signaling pathways. Recently, new genetic components in the oncogenic signaling in NB cells have been discovered. Despite these advances, details of down stream signaling and the relationship between these pathways remain elusive. Such knowledge is however crucial for ...