Projects
SOCIAL COGNITION AND ASSOCIATED DEFICITS: IN VIVO AND IN SILICO KU Leuven
We will investigate social cognition in the human brain. More specifically, we will use functional neuroimaging (fMRI) to image these essential social cognitive networks, in healthy controls and patients with deficits in social cognition (frontotemporal dementia or autismspectrum disorder). During MRI scanning, inclusions will perform a related social cognitive task. After analyses of MRI data, we will construct artificial neural networks, ...
An optical imaging system for in vivo bioluminescent and fluorescent imaging in small laboratory animals. KU Leuven
Unravelling neuron-glia interactions in Wolfram syndrome through optic nerve-on-chip and in vivo base editing KU Leuven
Wolfram syndrome (WS) is a rare hereditary disease, caused mainly by recessive mutations in the Wolfram syndrome 1 (WFS1) gene. It is characterized by endocrine abnormalities and neurodegeneration, including optic nerve atrophy. MRI of patients and mice demonstrated white matter changes (mainly oligodendrocyte dependent) and volume loss (mainly caused by loss of neurons). Oligodendrocyte and astrocyte abnormalities were also found in WFS1 ...
Trypanosomen in beeld : een vernieuwend model voor in vivo opvolging van Trypanosoma brucei infecties Institute of Tropical Medicine
In vivo PET of synaptic density in cognitive disorders: prospective evaluation of neuronal dysfunction and relation to symptomatology. KU Leuven
Currently, 18F-FDG PET is used for differential diagnosis in patients with cognitive dysfunction. It has the disadvantage that regional glucose metabolism is a combination of neuronal and astrocytic activity as well as neuroinflammation, which may mask true changes in synaptic activity. Imaging of SV2A serves as a proxy of synaptic density. This study will investigate and compare the diagnostic accuracy of 18F-SynVesT-1 to 18F-FDG PET in ...
Development of Imaging Methods towards Monitoring of Cell Therapy by In Vivo Magnetic Resonance Imaging KU Leuven
VIBRANT: In Vivo Imaging of Beta cell Receptors by Applied Nano Technology. KU Leuven
Cardiac remodeling after acute myocardial injury – understanding functional,cellular and molecular mechanisms by longitudinal in vivo imaging to reveal mechanisms for restoring endogenous cardioprotection. KU Leuven
Understanding the dissemination of Cryptococcus neoformans and Cryptococcus gattii - a longitudinal in vivo imaging study. KU Leuven
Cryptococcus neoformans and C. gattii are encapsulated yeasts that are opportunistic pathogens, affecting 1 million people/ year, predominantly by inhalation, leading to latent pneumonia. However, the most common and severe presentation is infection of the brain. The traversal of cryptococci across the blood-brain barrier (BBB) is a crucial step in its pathogenesis; but how and when this happens is still enigmatic. Experimental data suggests ...