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Project

Cardiac remodeling after acute myocardial injury – understanding functional,cellular and molecular mechanisms by longitudinal in vivo imaging to reveal mechanisms for restoring endogenous cardioprotection.

Ischemic heart disease is a leading cause of death. The metabolic, functional and structural changes after acute myocardial injury, a process termed cardiac remodeling, determine residual cardiac function, development of heart failure, and survival. Acute inflammatory response and therapeutic interventions including reperfusion not only contribute to infarct healing but paradoxicallyalso cause part of the injury. We propose different mouse models of ischemic injury and remodeling to better understand the effect onfunctional, cellular and metabolic mechanisms of cardiac remodeling.To understand the link between cardiac function, metabolism andoutcome, we will develop new in vivo imaging methods to acquirecardiac/respiration gated and simultaneously acquired positronemission tomography (PET) and magnetic resonance imaging (MRI)data.
Date:1 Oct 2020 →  Today
Keywords:acute myocardial injury, cardiac remodeling, ischemic injury, magnetic resonance imaging, positron emission tomography, molecular imaging, motion correction, preclinical models, postconditioning, inflammation
Disciplines:Cardiology, Medical imaging and therapy not elsewhere classified