Projects
Longitudinal measurement of synaptic density to monitor progression of Parkinson's disease and Huntington's disease KU Leuven
Increasing evidence from cell or animal models and postmortem human studies suggests that synaptic pathology is important in the early disease pathophysiology of Parkinson’s (PD) and Huntington’s disease (HD). PET imaging with 11C‑UCB‑J, targeting the presynaptic protein SV2A, provides an in vivo marker for synaptic density in the human brain. This thesis reports two multimodal imaging studies in people with early PD and early HD ...
Preclinical PET imaging of allele-selective mHTT lowering as candidate treatment for Huntington's Disease. University of Antwerp
Assessment of synaptic density and mHTT aggregates in post-mortem human brain tissue of patients with Huntington's Disease. University of Antwerp
Imaging methodology for Huntington's disease. University of Antwerp
Simultaneous in vivo measurement of the cerebral type 1 cannabinoid receptor and endocannabinoid levels in transgenic rats of Huntington's disease. KU Leuven
Dissecting the functional integrity of direct and indirect pathways of the dopaminergic system in Huntington's Disease University of Antwerp
Preclinical imaging of the brain cannabinoid receptors in Huntington's disease. KU Leuven
Genetics in everyday life. A qualitative study of individuals at risk of hereditary breast and ovarian cancer (BRCA) and Huntington’s disease (HD) about fears of genetic discrimination KU Leuven
For decades, as our understanding of human genetics has continued to advance, socio-ethical and legal scholars have raised questions and concerns about the ethical and social implications (ELSI issues) of genetics. One specific ELSI concern is that increased knowledge and applications of human genetics might lead to new forms of negative treatment, discrimination, and stigmatisation. In the nineties, several Western countries responded to ...