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- Research interest:Molecular imaging using positron emission tomography and single photon emission tomography. With these techniques we can image molecular and functional processes in humans and rodents through the use of radioactive tracers that are injected into the body and will visualise specific targets and processes in the living body. The technique is used in preclinical and clinical research and in the clinic (nuclear medicine). I’m particularly interested in methodological aspects of the technique to ensure the most optimal imaging results. This includes study design, image reconstruction, motion correction, imaging awake animals, tracer and therapy evaluation, pharmacokinetic modelling as well as translational aspects ensuring a cross-fertilization between pre-clinical and clinical research. Currently I’m applying these techniques for the neurosciences and pathologies such as Alzheimer's disease, Huntington’s disease schizophrenia.
- Keywords:MOTION CORRECTION, PHARMACOKINETICS, PET SCAN, IMAGE RECONSTRUCTION, HUNTINGTON DISEASE, Medicine
- Disciplines:Biomedical image processing, Biomedical modelling, Biomarker evaluation, Nuclear imaging, Neurosciences not elsewhere classified
- Research techniques:Positron emission tomographyAwake animalsMotion correctionPharmacokinetic modelingPET tracer validationPET image reconstruction
- Users of research expertise:Biomedical researchPharmaceutical research