New insights into ER and Golgi N-linked glycosylation - Contribution of CDG patients. KU Leuven
Congenital Disorders of Glycosylation (CDG) are a rapidly growing and heterogeneous group of rare, genetic diseases of metabolism. They are severe diseases that are caused by a defective glycosylation of proteins. However, the mechanisms of the fine-tuning of the glycosylation machinery remain poorly understood. Recent evidence, obtained from observations in specific patients, suggested that an adequate maintenance of the Golgi environment in ...