Projects
Identifying Genetic Correlates of HIV-1 Drug Resistance Using a Multifaceted Approach: Genotype-Treatment, Genotype-Phenotype, and Genotype-Clinical Outcome Correlations KU Leuven
HIV-1 drug-resistance knowledge is critical for antiretroviral (ARV) drug design, the management of HIV-1 infected patients, and estimating transmitted drug resistance (TDR). However, understanding the genetic basis of HIV-1 drug resistance is hindered by the high levels of naturally occurring polymorphisms and large numbers of mutation patterns associated with cross-resistance within each antiretroviral drug class.
I studied three ...
The Belgian prenatal microarray database (BEMAPRE): realization of the database, determination of genotype-phenotype correlations and postnatal follow-up. University of Antwerp
Unraveling neuromuscular spectrinopathies through SPTAN1 genotype-phenotype correlations University of Antwerp
Genetics of Dravet syndrome – from genotype-phenotype correlations to disease modeling in zebrafish. University of Antwerp
MOLECULAR DIAGNOSTICS IN AUTISM SPECTRUM DISORDER: NEXT GENERATION SEQUENCING AND FACIAL PHENOTYPING IN MEDICAL GENETICS KU Leuven
Despite considerable progress in the genetics of autism spectrum disorder (ASD) in the past decade, molecular diagnostics for patients with ASD remains a great challenge due to the complex genetic architecture of ASD. In clinical genetics, an etiological distinction is usually made between ASD patients with Mendelian causes (i.e. driven by a highly penetrant rare variant) and patients with multifactorial causes (i.e. driven by many genetic ...
Machine learning in federated analytics KU Leuven
An important emerging trend in the analysis of sensitive medical data is federated machine learning, where computations are executed in a decentralized manner that does not require the sharing of sensitive patient-level data but learns machine learning models only from aggregated statistical data (typically, from the participating clinical center or a national biobank or registry). Such approaches naturally implement the data minimization ...