Projects

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Exercise therapy in Multiple Sclerosis, do we need to revise the traditional moderate to vigorous intensity exercise paradigm? Hasselt University

Bert OP 'T EIJNDE
Cardio & organ systems
Exercise therapy has become an integral part of Multiple Sclerosis (MS) treatment. So far, a multitude of higher intensity exercise therapy (HIT) studies have shown substantial improvements in a variety of MS related functional disabilities (e.g. reduced exercise capacity and muscle strength) important to perform daily life activities. However, these disease symptoms also result in an inactivity-related physiological profile leading to impaired ...

Exercise therapy in Multiple Sclerosis, do we need to revise the traditional moderate to vigorous intensity exercise paradigm? Hasselt University

Bert OP 'T EIJNDE
Cardio & organ systems
Exercise therapy has become an integral part of Multiple Sclerosis (MS) treatment. So far, a multitude of higher intensity exercise therapy (HIT) studies have shown substantial improvements in a variety of MS related functional disabilities (e.g. reduced exercise capacity and muscle strength) important to perform daily life activities. However, these disease symptoms also result in an inactivity-related physiological profile leading to ...

T-EX: Technology-based exercise protocols for knee osteoarthritis: A computational modeling framework combined with wearable technology, to support patient-specific exercise protocols in knee OA patients. KU Leuven

Ilse Jonkers
Human Movement Biomechanics Research Group, Research Group for Musculoskeletal Rehabilitation

Osteoarthritis (OA) is the most common chronic joint disease, for which no cure exists to reverse or stop progression. Joint loading plays an important role in cartilage homeostasis and therefore atypical joint loading is known to accelerate OA progression. Patientspecific exercise protocols, aiming to restore typical joint loading during daily life activities, therefore, holds the potential to slow down OA progression. We will leverage the ...

Genetic determinants of exercise performance and the response to exercise training in heart disease. The renin angiotensin system, autonomic, endothelial and muscular function. KU Leuven

Luc Vanhees
Experimental Cardiology, Research Group for Rehabilitation in Internal Disorders, Hypertension and Cardiovascular Epidemiology
To unravel pathways behind the associations between genetic variation and aerobic power or its response to physical training, a prospective study will be performed in 300 patients with CAD. These patients will follow a standardized physical training programme for three months at three exercise sessions weekly, with an average duration of 90 minutes per session. The physical training programme will consist of a combination of strength training ...

Physical Exercise to Bounce back from Perseverative Cognition: Focus on Bottom-UP and Top-Down Influences of the Heart-Brain Nexus Ghent University

Marie-Anne Vanderhasselt
Department of Experimental clinical and health psychology, Department of Head and Skin

Perseverative Cognition (PC), i.e. intrusive, uncontrollable, repetitive thoughts regarding past stressful events or feared future outcomes, plays a crucial role in stress recovery. These PCs are associated with imbalances in the heart-brain nexus, reflected in reduced parasympathetic control (over sympathetic reactivity) and reduced prefrontal control (over limbic reactivity). Research has shown that physical exerciseU+2014regular and ...

A novel exercise physiology mechanism in human muscle: the carnosine-histidine-histamine pathway Ghent University

Wim Derave
Department of Movement and Sports Sciences

Physical exercise is an effective preventive and therapeutic strategy to chronic diseases such as type-II diabetes and obesity, hence the term U+201CEXERCISE IS MEDICINEU+201D. A considerable portion of these health-promoting effects relate to the acute and chronic vascular adaptations to exercise. We now propose a putative CARNOSINE-HISTIDINE-HISTAMINE PATHWAY as a molecular mediator of these health-protective effects. CARNOSINE is an ...

The Exercise and Nutrition for Healthy AgeiNg (ENHANce) project: optimized and individualized anabolic interventions to improve physical performance in sarcopenic community-dwelling older persons. KU Leuven

Evelien Gielen
Gerontology and Geriatrics

Sarcopenia is the loss of muscle mass and function with ageing. It is a hot topic in geriatric medicine due to its increasing prevalence and far-reaching consequences such as immobility, falls, fractures and death. To treat sarcopenia, we developed the Exercise and Nutrition for Healthy AgeiNg (ENHANce) project, in which we examine the effect of proteins with or without omega-3 fatty-acid supplements on top of a physical exercise program. The ...

Induce pain to relieve pain: The effect of "exercise into discomfort" on clinical outcomes and ultrasound imaging parameters in patients with subacromial shoulder pain. University of Antwerp

Filip Struyf
Movement Antwerp (MOVANT)
The rotator cuff (RC) is a group of muscles and tendons that allows to move the shoulder, keeping the upper arm bone in the shoulder blade socket. An injury in the RC can cause swelling and irritation of these structures, making arm movements painful. This subacromial shoulder pain (SSP) can be caused by a combination of intrinsic factors (degeneration) and extrinsic factors (compression of the RC). Exercise therapy is the first choice of ...

Lifetime endurance exercise to prevent coronary artery disease. A comparison with late-onset endurance training and a sedentary lifestyle. KU Leuven

Rik Willems
Cardiology

The aim of this project is to validate lifetime endurance exercise as a way of coronary prevention and thus provide a scientific basis for the implementation of endurance exercise programs in Flanders. We want to identify risk factors that are associated with the occurrence of side effects of endurance exercise, namely the occurrence of atrial fibrillation and manifest myocardial fibrosis. Through a better understanding of the dose-response ...

Counteracting sarcopenia through exercise. KU Leuven

Christophe Delecluse
Physical Activity, Sports & Health Research Group
The aging of population poses many challenges to our society. A major public health concern is the age-related decline in functionality, which threatens the independency and quality of life of older adults. This functional decline has been shown to be associated with the phenomenonof sarcopenia, first introduced by dr. I.H. Rosenberg as the age-related decrease in skeletal muscle mass.
As our understanding of the complex process of aging ...