Genetic determinants of exercise performance and the response to exercise training in heart disease. The renin angiotensin system, autonomic, endothelial and muscular function.

To unravel pathways behind the associations between genetic variation and aerobic power or its response to physical training, a prospective study will be performed in 300 patients with CAD. These patients will follow a standardized physical training programme for three months at three exercise sessions weekly, with an average duration of 90 minutes per session. The physical training programme will consist of a combination of strength training and endurance training During this study an anonymously coded blood sample will also be drawn from each patient for genotyping for the genetic variants that were previously investigated in the CAREGENE study. In addition to the genetic profile and aerobic power, information will be obtained concerning cardiovascular dynamics, the autonomic and endothelial function, peripheral muscle strength and the renin-angiotensin system.

Keywords:Heart disease, Training

Disciplines:Cardiac and vascular medicine, Orthopaedics, Human movement and sports sciences, Rehabilitation sciences, Laboratory medicine, Medical systems biology, Molecular and cell biology