Projects
A spatial multi-omics approach to determine the earliest clonal alterations underlying head and neck carcinogenesis. Ghent University
Somatic mutations are small DNA errors that accumulate in the genome of ageing cells. These mutations sporadically result in a cellular growth advantage, especially when they occur in cancer genes. The sequential accumulation of these so-called driver mutations eventually leads to the formation of malignant tumors. Recent evidence suggests that they also underlie micro-clone formation in multiple histologically normal epithelial tissues, ...
Evaluating the function and the therapeutic potential of IFN-λ in intestinal carcinogenesis Ghent University
Colorectal cancer is the third most common malignancy and the fourth leading cause of cancerrelated
deaths in the world, and its burden is expected to increase to more than 1,1 million deaths
per year by 2030. Better understanding of the carcinogenesis mechanisms is needed to improve
treatment strategies. Type I interferons (IFNs) exert diverse roles in the immune system and harbour
cytotoxic and anti-proliferative ...
Crosstalk between MUC13 signalling and the mucosal microbiota in gastric cancer development. University of Antwerp
Targeting the Hippo pathway for cancer therapy: Discovering endogenous tumor suppressor mechanisms KU Leuven
Cancer is a leading cause of death worldwide, currently responsible for about 10 million deaths every year. Unfortunately, despite extensive research within this field, how cancer originates is not completely understood. The predominant theory about the genesis of cancer suggests that it arise when cells accumulate a certain amount of driver mutations. These mutations reprogram normal cells into cancerous cells, through progressive changes ...
Improving current cancer detection and treatment follow up through the development of next generation cancer assays. University of Antwerp
Research and applications in biological image and signal processing. University of Antwerp
In depth analysis of two novel human gene families implicated in carcinogenesis and tumor progression. Ghent University
Several human cancers are still poorly understood at the molecular level. Recently, we discovered a novel gene family, called NBPF for Neuroblastoma BreakPoint gene Family, whose members are localized on chromosome 1 in regions that are often deleted or amplified in various tumor types. On the other hand, there is growing evidence for involvement of several members of the newly defined delta-protocadherin gene family in human cancer. We have ...
MYCOLON - A mechanistic approach to map the interplay of mycotoxins and gut epithelium towards colorectal cancer risk Ghent University
Mycotoxins are fungal secondary metabolites that contaminate a wide spectrum of foods worldwide. Mycotoxins exert a diversity of human health threats, including carcinogenesis with the most common & pathologically-significant mycotoxins being aflatoxins, fumonisins, trichothecenes (e.g. deoxynivalenol (DON)) & patulin (PAT). MYCOLON is based on preliminary data identifying DON & PAT as mycotoxins with the highest potential to ...
MYCOLON - A mechanistic approach to map the interplay of mycotoxins and gut epithelium towards colorectal cancer risk Ghent University
Mycotoxins are fungal secondary metabolites that contaminate a wide spectrum of foods worldwide. Mycotoxins exert a diversity of human health threats, including carcinogenesis with the most common & pathologically-significant mycotoxins being aflatoxins, fumonisins, trichothecenes (e.g. deoxynivalenol (DON)) & patulin (PAT). MYCOLON is based on preliminary data identifying DON & PAT as mycotoxins with the highest potential to ...