Projects

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Understanding the role of the WNT signaling pathway in breast cancer dormancy, therapy resistance and cancer relapse. KU Leuven

Frederic Lluis Vinas
Stem Cell and Developmental Biology

From all cancer types, breast cancer is the most frequent and most deadly among women. In Europe, Belgium ranks first in breast cancer incidence and, according to the Belgian Cancer Registry, the yearly number of cases is expected to keep rising. Breast cancer has several clinical subtypes with different treatment options. Triple Negative Breast Cancer (TNBC) is an aggressive subtype for which specific treatment options are not available. As ...

Improving current cancer detection and treatment follow up through the development of next generation cancer assays. University of Antwerp

Guido Van Camp
Center for Oncological Research (CORE), Human molecular genetics
Each year, an estimated 8.2 million people die of cancer. With appropriate detection methods and treatment, many of these deaths would be avoidable. However, current methods for detection and analysis of treatment response still suffer from major disadvantages. An attractive novel method is the detection of abnormally expressed biological markers manifested during carcinogenesis in so called "liquid biopsies". Liquid biopsy is a technique in ...

Improving current cancer detection and treatment follow-up through the development of a next generation cancer assay. University of Antwerp

Guido Van Camp
Center for Oncological Research (CORE), Human molecular genetics
Each year, an estimated 8.2 million people die of cancer. With appropriate detection methods and treatment, many of these deaths would be avoidable. Due to the high incidence and mortality rates, early and accurate diagnosis is paramount for a quick and adequate treatment of patients. Until recently, no truly non-invasive diagnostic methods for the detection of cancer existed. An attractive novel method is the detection of abnormally expressed ...

Pain Education after CANcer (PECAN)-app: a new, innovative delivery method for pain science education in breast cancer survivors University of Antwerp

An De Groef
Movement Antwerp (MOVANT)
Both in research and in clinical practice, interest in pain science educational interventions for treatment of persistent pain after breast cancer treatment has increased significantly over the past decades. Modern Pain Science Education (PSE) explains the neurophysiology of (chronic) pain, the nervous system's ability to modulate and perpetuate the pain experience, and highlights the influence of other factors (such as sleep, thoughts, ...

Damage-associated molecular patterns and immunogenic cancer cell death in cancer immunotherapy KU Leuven

Abhishek Garg
Laboratory of Cell Death Research & Therapy (VIB-KU Leuven)
My research is focused on cancer immunology and immunotherapy (e.g. anticancer vaccines, immunogenic cell death, immune effector responses), photodynamic therapy, combinatorial therapies involving chemo-(radio-)therapy and novel immunostimulatory factors (e.g. damage-associated molecular patterns/DAMPs, chemokines and cytokines). I have (and continue to) delineated novel cancer signalling (e.g. danger signalling, immunogenic signalling, ...

Room for Vulnerability: How can the lived Experience of Children and Youth affected by Cancer inform the Design of Cancer Care Facilities? KU Leuven

Ann Heylighen
Education and Society, Architecture and Design

In diverse disciplines attention grows for the built care environment and its impact on the quality of care, quality of life, and wellbeing of people affected by cancer. The perspective and experiences of children and youth affected by cancer largely remain underexposed so far, even though they are the main actors. Therefore the project seeks to provide designers and others responsible for the built care environment with insights and tools to ...

Unraveling the intriguing interplay between CD70+ cancer associated fibroblasts and colorectal cancer cells resulting in the identification of a potent biomarker and novel therapeutic target University of Antwerp

Vanessa Deschoolmeester
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Evidence of evolving crosstalk between colorectal cancer (CRC) cells and their microenvironment has been provided. We observed a high expression of CD70 in cancer associated fibroblasts (CAFs) present in CRC stroma of late stage disease. Consequently, we will investigate the clinical significance of the interplay between CD70+ CAFs and CRC cells as well as the value of an anti-CD70 mAb in advanced CRC.

Sexual, psychological and relational functioning in women after surgical treatment for gynaecological cancer and breast cancer KU Leuven

Frédéric Amant
Gynaecological Oncology, Interfaculty Institute for Family and Sexuality Studies, Surgical Oncology
The aim of the PhD project is to prospectively obtain detailed and realistic information about the anatomical changes and possible consequenceson sexuality, overall well-being and partner relationship after pelvic surgery for gynaecological pathology. All women who undergo pelvic surgery for benign or malignant gynaecological pathology are invited to participate our prospective study. After subjects gave written informed consent patients ...

To understand and suppress liver cancer cell plasticity and evolution KU Leuven

Tania Roskams
Translational Cell & Tissue Research, Laboratory of Growth Control and Cancer Research (VIB-KU Leuven Center for Cancer Biology)
The incidence of liver cancer is increasing worldwide and current therapies are ineffective. This is mainly because liver tumors are highly heterogeneous, allowing the evolution of therapy resistant sub-clones. Thus, the objective of this project is to understand and control cancer cell plasticity in liver cancer. We will first characterize the spectrum of the cellular heterogeneity present in liver cancer and then identify molecular mechanisms ...