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Project
Unraveling the intriguing interplay between CD70+ cancer associated fibroblasts and colorectal cancer cells resulting in the identification of a potent biomarker and novel therapeutic target
Evidence of evolving crosstalk between colorectal cancer (CRC) cells and their microenvironment has been provided. We observed a high expression of CD70 in cancer associated fibroblasts (CAFs) present in CRC stroma of late stage disease. Consequently, we will investigate the clinical significance of the interplay between CD70+ CAFs and CRC cells as well as the value of an anti-CD70 mAb in advanced CRC.
Date:1 Feb 2015 → 31 Dec 2015
Keywords:CANCER ASSOCIATED FIBROBLASTS, CD70, ADENOCARCINOMA COLON
Disciplines:Laboratory medicine, Morphological sciences, Oncology, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other clinical sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences