Organisations
Laboratory of Cell Death Research & Therapy (VIB-KUÂ Leuven) KU Leuven
The Laboratory of Cell Death Research & Therapy researches Defective regulation of cell death, especially in the form of apoptosis, contributes to the development of crucial pathologies including cancer and plays a major role in chemoresistance. Mechanisms regulating cancer cell death also affect the emission of ‘danger signals’ from the stressed/dying cells, which critically define their ‘immunogenic character’ and impact the initiation ...
Laboratory of Cell Stress & Immunity KU Leuven
The Laboratory for Cell Stress & Immunity (CSI) focusses on following research themes: cancer immunology & immunotherapy (e.g. DC vaccines, immune-checkpoint blockers, chemo-immunotherapy), immunology of cancer cell death (e.g. programmed cell death like apoptosis, necrosis & necroptosis; stress responses, inflammation, immunity), stress or therapy-elicited immune-signalling pathways (e.g. type I interferons, NFkB signalling, ...
Cell Genetics Vrije Universiteit Brussel
The laboratory for Cell Genetics (Cytogenetics) studies variation in genotype and phenotype, cell division pathways, cell death and genetic changes relevant for the increase of cancer in human. Genotoxicity tests assess the induction of DNA damage, gene mutations, structural and numerical chromosome aberrations. Their predictivity for cancer induction is supported by international studies relating mutations and activation of cancer related ...
Translational Cell & Tissue Research KU Leuven
Using a large panel of classical morphological techniques incl. enzyme- andimmunohistochemistry, as well as more advanced molecular techniques on tissue sections, we investigate the histology & the function of a variety of human tissues in normal & in pathological conditions.Throughout these research activities we attempt to optimise the available morphological techniques for light microscopy, electron microscopy, incl. transmission ...
Vandenabeele Lab Flanders Institute for Biotechnology
Forensic Biomedical Sciences KU Leuven
The research of the Forensic Biomedical Sciences group integrates scientific and clinical disciplines within a multidisciplinary program with a focus on forensic genetics, molecular archaeology and forensic medicine.
Toxicology, Dermato-cosmetology and Pharmacognosy Vrije Universiteit Brussel
Topic A: Experimental in vitro toxicology: The use of isolated hepatocytes and their cultures for pharmaco- toxicological studies with focus on phase I and phase II biotransformation of xenobiotics; liver zonation of xenobiotic transformation; cell cycle and molecules affecting cell progression and cell signaling; the role of apoptosis in cell cultures; connexins and their importance in cell signaling. Topic B: Dermato-Cosmetic Sciences: ...
Molecular Digestive Oncology KU Leuven
The laboratory for Molecular Digestive Oncology focusses on gastro-intestinal cancers and currently has two types of activities:
- large molecular annotation projects, aimed at better describing the overall molecular identity of GI tumors and potential subtypes. Activities here include in depth molecular annotation of tumor series, state of the art bioinformatics for subtype derivation and biological annotation, comparisons of ...
Neuro-Aging & Viro-Immunotherapy Vrije Universiteit Brussel
The ‘Neuro-Aging’ team focuses on glutamate transport, with emphasis on system xc - , in health and disease. We have ongoing projects on the role of system xc - or the cystine/glutamate antiporter in e.g. Parkinson’s disease, Alzheimer’s disease, and (central effects of) (pancreatic) cancer. In most of these projects, neuroimmune communication is receiving increasing attention. Our overall hypothesis that inhibition of system xc - might be a ...