Projects
Interplay between the endoplasmic reticulum, Ca2+ and autophagy induced by various stressors KU Leuven
Autophagy is an evolutionary conserved degradation process responsible for the removal of superfluous or damaged proteins and organelles. Autophagy maintains cellular health during stress conditions like nutrient or growth-factor depletion and is implicated in many diseases like cancer and neurodegeneration. The endoplasmic reticulum (ER), the major organelle for protein and lipid synthesis and for intracellular Ca2+ storage, plays a central ...
Molecular and functional characterization of the IP3R protein complexes with Beclin-1 and Bcl2/BclXl during autophagy. KU Leuven
Tissue-specific induction of autophagy as an innovative therapeutic strategy in cardiovascular and metabolic disease. (CARDIOPHAGY). University of Antwerp
ACTIVATE: Autophagy is a master regulator for the immune funCTions of the lymph node VasculATurE KU Leuven
Lymph nodes (LNs) sequester antigens to educate immune cells and mount immunological responses. Under homeostasis, lymphatic vessels (LVs) deliver immune cells and antigens from peripheral tissues and are the major route of lymphocyte efflux, meanwhile high endothelial venules (HEVs) extract lymphocytes from the blood stream to be primed by antigens, thus both are essential to lymphocyte education. Autophagy is a major degradative pathway ...
Train your defence system: muscle-derived myokines tackle immune aging by boosting autophagy Hasselt University
Preclinical characterization and biopharmaceutical optimization of the autophagy inhibitor UAMC-2526 for oncotherapy. University of Antwerp
Harnessing autophagy in the tumour stroma to improve anti-tumour immunity KU Leuven
Cutaneous malignant melanoma is one of the most aggressive cancer types. Anti-melanoma immunotherapies have shown great promise recently but still face limited clinical success in certain subset of patients due to tumor-elicited immunosuppression. Previous published and current preliminary data from our lab demonstrates that the genetic disruption of autophagy (a major catabolic pathway, especially in melanoma) in vascular endothelial cells ...