The continued spread of anti-microbial resistant bacterial pathogens together with a lag in the development of suitable antibiotic alternatives set the alarm bells ringing in public and animal health. In this project proposal, ImmunoKeys, synthetic biology and animal immunology experts join forces to engineer microbial cell factories capable of producing structurally well-defined (partially acetylated) chitooligosaccharides with optimal ...
The research is concerned with the animal's position in society, using the concept of 'One Welfare', which focuses on the interaction between the welfare of animals, human beings and their environment. 'One Welfare' is considered to be an extension of the 'One Health' theme, with which it partly overlaps. The last few months it has become even more clear that the health and welfare of human beings cannot be seen separately from the health and ...
The project has two connected aims: (1) to analyse and assess LeibnizU+2019s treatment of what he calls U+2018animal economyU+2019 (roughly speaking, the physiology of macro-scale living bodies) and (2) to show that he is an explanatory pluralist with respect to biology. The project addresses the accounts of U+2018animal economyU+2019 alongside LeibnizU+2019s metaphysical treatment of biology (most famously, in the form of his monads). The ...
Molecular imaging allows non-invasive in vivo visualization, characterization and quantification of biological and pathophysiological processes that can be longitudinally monitored in specific (transgenic) animal models of human diseases in a physiological environment. The hybrid small animal PET-CT system will provide molecular information with high sensitivity and submillimeter resolution co-registered with anatomical information within one ...
In this OT project, (epi)genetic large-scale studies in combination with functional in vitro studies will be used to characterize patients with “rare inherited Bleeding and Platelet Disorders (BPDs)”. (Epi)Genetic studies and system biology approaches to characterize rare inherited bleeding and platelet disorders: from patient studies to basic biology to clinical applications.
Animal communication signals typically evolve because of a shared interest between the signaling and receiver individuals. In the present project, I will make the first systematic empirical and theoretical study of another class of signals, where the receiver instead is partly manipulated or “deceived”. To do so, I will use insect societies as my key model system, and study how four classes of manipulative signals that have been previously ...
The Antarctic and the surrounding Southern Ocean contain delicate and unique ecosystems, characterised by a cold climate, a seasonal photoperiod, remote location and a endemic fauna. Compared to other oceans, the Southern Ocean exhibits low species richness, but despite this, the Southern Ocean is still characterized as an evolutionary hotspot. The adaptive radiation of the notothenioids, the predominant clade of fishes in the Southern Ocean ...
EFFORT studies the complex epidemiology and ecology of antimicrobial resistance and the interactions between bacterial communities, commensets and pathogens in animals, the food chain and the environment. This will be conducted by a combination of epidemiological and ecological studies using newly developed molecular and bio-informatics technologies, EFFORT will include an exposure assessment of humans from animal/environmental sources.