The cell biology of γ-secretase: New advances in understanding its assembly, trafficking and interactions KU Leuven
From the moment Alzheimer's disease (AD) causing mutations were discovered in the PSEN genes, its protein products, presenilins (PSEN), have been in the center of attention for AD research. While their function as the catalytic component of the tetrameric intramembrane protease, γ-secretase, was described, pieces of the puzzle started coming together. However, decades later, many questions remain about its biology, exact role in the development ...