Projects
Unravelling the mechanisms of immunomodulation by Schistosoma mansoni proteins in a mouse model of chronic colitis. University of Antwerp
Liver and systemic haemodynamic alterations, noninvasive diagnostic markers and potential pathophysiological mechanisms for NAFLD and NASH: a large longitudinal cohort study. University of Antwerp
Study on the mechanisms underlying mast cell activation in postinfectious visceral hypersensitivity KU Leuven
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder characterized by chronic discomfort and abdominal pain associated with altered defecation in the absence of an organic cause. It is becoming increasingly clear that mast cell activation, leading to activation and sensitization of afferent nerves, plays a crucial role in abnormal visceral pain sensation (visceral hypersensitivity), one of the hallmarks of IBS. However, the ...
The role of afferent neurons and their modulation in the pathogenesis of postinflammatory gastrointestinal motility and sensitivity disturbances. University of Antwerp
The role of afferent nerves in the pathogenesis of post-inflammatory gastrointestinal motility and sensitivity disturbances in the rat. University of Antwerp
Characterisation and modulation of the enteric neuroimmune environment during endotoxin-induced ileus. University of Antwerp
Interference of colonic luminal compounds with the mucosal butyrate metabolism in ulcerative colitis. KU Leuven
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) which is characterised by chronic, relapsing inflammation of the colonic mucosa. The most common clinical symptoms include bloody diarrhoea, abdominal pain, fatigue and weight loss. Conventional therapeutic options are mainly targeted at reducing the inflammatory process but are only partially successful and associated with a range of side effects. The exact patho-physiological ...