Researcher
Sophie Janssens
- Keywords (Ghent University):IRE1, dendritic cell biology, unfolded protein response
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Cell signalling, Inflammation, Innate immunity, Intracellular compartments and transport
- See also: Sophie Janssens (Flanders Institute for Biotechnology)
Affiliations
- Department of Internal Medicine and Pediatrics (Department)
Member
From1 Oct 2018 → Today - Janssens Lab (Research group)
Responsible
From1 Mar 2018 → Today - Lambrecht and Hammad Lab (Research group)
Member
From1 Jan 2017 → 28 Feb 2018 - Department of Internal medicine (Department)
Member
From1 Mar 2011 → 30 Sep 2018 - Department of Biomedical molecular biology (Department)
Member
From1 Apr 1998 → 30 Sep 2007
Projects
1 - 10 of 13
- LNP-DECODE: Deciphering the adjuvants activity of lipid nanoparticle-based mRNA vaccines in primary dendritic cellsFrom1 Jan 2024 → TodayFunding: BOF - projects
- Decoding tumor antigens: dendritic cell maturation within the tumor environmentFrom1 Oct 2023 → TodayFunding: BOF - projects
- Molecular mechanism and functional implications of the AGR2-IRE1ß axis in goblet cell homeostasisFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomicsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Dissecting the molecular signals that drive immunogenic versus homeostatic maturation in dendritic cells. An old question revisited.From1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding the role of Notch in Dendritic Cell biologyFrom1 Nov 2021 → TodayFunding: FWO fellowships
- Replacement and extension of basic infrastructure in the histology core facility.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- IRE1 as a regulator of apoptotic cell engulfment in macrophages.From1 Nov 2020 → TodayFunding: FWO fellowships
- The IRE1/XBP1 signaling axis in dendritic cell-mediated anti-tumor immune responsesFrom15 Nov 2019 → 31 Aug 2023Funding: BOF - doctoral mandates
- A novel role for the IRE1/XBP1 branch in dendritic cells: a signaling cascade matures.From1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
Publications
1 - 10 of 19
- Type 1 immunity enables neonatal thymic ILC1 production(2024)
Authors: Peter Tougaard, Mario Ruiz Pérez, Wolf Steels, Jelle Huysentruyt, Bruno Verstraeten, Jessica Vetters, Tatyana Divert, Amanda Gonçalves, Ria Roelandt, Nozomi Takahashi, et al.
- Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown(2024)
Authors: Quentin Reuschlé, Laurien Van Heddegem, Victor Bosteels, Matthieu Moncan, Sabine Depauw, Nadège Wadier, Sandra Maréchal, Clint De Nolf, Virginia Delgado, Yosra Messai, et al.
- The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice(2022)
Authors: Bastiaan Maes, Ursula Smole, Matthias Vanderkerken, Kim Deswarte, Justine Van Moorleghem, Karl Vergote, Manon Vanheerswynghels, Caroline De Wolf, Sofie De Prijck, Nincy Debeuf, et al.
Pages: 1413 - 1427.e2 - TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C(2022)
Authors: Levi Hoste, Lisa Roels, Leslie Naesens, Victor Bosteels, Stijn Vanhee, Sam Dupont, Cédric Bosteels, Robin Browaeys, Niels Vandamme, Kevin Verstaen, et al.
- The UPR sensor IRE1 alpha promotes dendritic cell responses to control Toxoplasma gondii infection(2021)
Authors: Anais F. Poncet, Victor Bosteels, Eik Hoffmann, Sylia Chehade, Sofie Rennen, Ludovic Huot, Veronique Peucelle, Sandra Maréchal, Jamal Khalife, Nicolas Blanchard, et al.
- A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism(2021)
Authors: Leen Catrysse, Bastiaan Maes, Parul Mehrotra, Arne Martens, Esther Hoste, Liesbet Martens, Christian Maueröder, Anneleen Remmerie, Anna Bujko, Karolina Slowicka, et al.
- IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress(2020)
Authors: Michael J. Grey, Eva Cloots, Mariska S. Simpson, Nicole LeDuc, Yevgeniy V. Serebrenik, Heidi De Luca, Delphine De Sutter, Phi Luong, Jay R. Thiagarajah, Adrienne W. Paton, et al.
- ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids(2020)
Authors: Srinath Govindarajan, Eveline Verheugen, Koen Venken, Djoere Gaublomme, Margaux Maelegheer, Eva Cloots, Fien Gysens, Bruno De Geest, TanU+2010Yun Cheng, D Branch Moody, et al.
- The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice(2019)
Authors: Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, et al.
Pages: 1648 - 1659 - The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF(2019)
Authors: Jessica Vetters, Mary van Helden, Sigrid Wahlen, Simon Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, et al.
Pages: 2010 - 2023