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Project
The IRE1/XBP1 signaling axis in dendritic cell-mediated anti-tumor immune responses
The aim of this project is to characterize the contribution of IRE1, a sensor of the unfolded protein response (UPR), in dendritic cells which present tumor derived antigens to CD8 T cells. A thorough understanding of the UPR in tumor antigen crosspresentation by dendritic cells is essential to improve current immunotherapies.
Date:15 Nov 2019 → 31 Aug 2023
Keywords:antigen presentation, unfolded protein response, XBP1, dendritic cell tolerance, cancer, Dendritic cell, ER stress, IRE1, anti-tumor immune response
Disciplines:Cell signalling, Adaptive immunology, Inflammation