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Researcher
Sandra Liekens
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Department of Microbiology, Immunology and Transplantation (Department)
Member
From1 Dec 2019 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 31 Dec 2019
Projects
1 - 7 of 7
- Structure-based discovery of positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor as cognition enhancers.From1 Oct 2016 → 30 Sep 2018Funding: IOF - Industrial Research Fund
- Vascular-disrupting agents (VDA): mechanism of action and anti-tumor activityFrom1 Feb 2016 → 6 Jan 2017Funding: Own budget, for example: patrimony, inscription fees, gifts
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Role of receptor tyrosine kinases and associated gangliosides in influenza virus replicationFrom1 Oct 2012 → 21 Dec 2020Funding: BOF - Doctoral projects
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- Dengue virus infection of endothelial cells: Pathogenesis and antiviral potential of glycosaminoglycan targetingFrom1 Sep 2009 → 29 Sep 2015Funding: Own budget, for example: patrimony, inscription fees, gifts
- The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analoguesFrom1 Jun 2008 → 2 Dec 2013Funding: IWT personal funding - strategic basic research grants
Publications
21 - 30 of 113
- Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: design, synthesis and antiproliferative activity(2018)
Authors: Sam Noppen, Sandra Liekens
Pages: 337 - 348 - High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design(2018)
Authors: Sandra Liekens
Pages: 4242 - Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents(2018)
Authors: Sandra Liekens
Pages: 183 - 193 - New findings on the d(TGGGAG) sequence: surprising anti-HIV-1 activity(2018)
Authors: Sandra Liekens, Sam Noppen, Christophe Pannecouque
Pages: 425 - 430 - Modulation of BACE1 Activity by Chemically Modified Aptamers(2018)
Authors: Sam Noppen, Mikhail Abramov, Sandra Liekens, Bart De Strooper, Piet Herdewyn
Pages: 754 - 763 - 2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells(2018)
Authors: Sam Noppen, Wim Dehaen, Jan Balzarini, Sandra Liekens
Pages: 6259 - 6269 - Different positions of amide side chains on the benzimidazo[1,2-: A] quinoline skeleton strongly influence biological activity(2018)
Authors: Sandra Liekens, Arthur Van Aerschot, Peter Vervaeke, Bharat Gadakh
Pages: 7096 - 7104 - Bis coumarinyl bis triazolothiadiazinyl ethane derivatives: Synthesis, antiviral activity evaluation, and molecular docking studies(2018)
Authors: Lieve Naesens, Sandra Liekens
Pages: 1494 - 1503 - 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition(2018)
Authors: Jan Balzarini, Sandra Liekens
Pages: 683 - 698 - An allosteric binding site of the alpha 7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein(2018)
Authors: Fabian Gruss, Sam Noppen, Steve Peigneur, Patrick Chaltin, Sandra Liekens, Jan Tytgat, Chris Ulens
Pages: 2534 - 2545
Patents
1 - 2 of 2
- Novel anti-cancer thiophene compounds (Inventor)
- Anti-cancer compounds (Inventor)