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Researcher
Sandra Liekens
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Department of Microbiology, Immunology and Transplantation (Department)
Member
From1 Dec 2019 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 31 Dec 2019
Projects
1 - 7 of 7
- Structure-based discovery of positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor as cognition enhancers.From1 Oct 2016 → 30 Sep 2018Funding: IOF - Industrial Research Fund
- Vascular-disrupting agents (VDA): mechanism of action and anti-tumor activityFrom1 Feb 2016 → 6 Jan 2017Funding: Own budget, for example: patrimony, inscription fees, gifts
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
- Role of receptor tyrosine kinases and associated gangliosides in influenza virus replicationFrom1 Oct 2012 → 21 Dec 2020Funding: BOF - Doctoral projects
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- Dengue virus infection of endothelial cells: Pathogenesis and antiviral potential of glycosaminoglycan targetingFrom1 Sep 2009 → 29 Sep 2015Funding: Own budget, for example: patrimony, inscription fees, gifts
- The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analoguesFrom1 Jun 2008 → 2 Dec 2013Funding: IWT personal funding - strategic basic research grants
Publications
31 - 40 of 113
- Relative distribution and biological characterization of CXCL4L1 isoforms in platelets from healthy donors(2017)
Authors: Pieter Ruytinx, Rik Janssens, Mieke Gouwy, Sandra Liekens, Paul Proost, Jo Van Damme, Sofie Struyf
Pages: 123 - 131 - Tumor angiogenesis revisited: Regulators and clinical implications(2017)
Authors: Mohammed Benkheil, Sofie Struyf, Sandra Liekens
Pages: 1231 - 1274 - Regioselective monoalkylation of 17β-estradiol for the synthesis of cytotoxic estrogens(2017)
Authors: Sandra Liekens
Pages: 54 - 59 - Synthesis and anticancer activity of novel aza-artemisinin derivatives(2017)
Authors: Sampad Jana, Sandra Liekens, Wim Dehaen
Pages: 3671 - 3676 - Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses(2017)
Authors: Jan Balzarini, Kalyan Das, Sandra Liekens
Pages: 51 - 61 - Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes(2017)
Authors: Rik Janssens, Daiane Boff, Pieter Ruytinx, Mieke Gouwy, Olav Larsen, Sam Noppen, Sandra Liekens, Jo Van Damme, Sofie Struyf, Paul Proost
Pages: 92 - 101 - A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes(2017)
Authors: Sampad Jana, Jan Balzarini, Sandra Liekens, Wim Dehaen
Pages: 3892 - 3900 - Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes(2017)
Authors: Els Vanstreels, Wim Dehaen, Sandra Liekens, Jan Balzarini
Pages: 219 - 235 - A multitarget approach toward the development of 8-substituted purines for photoprotection and prevention of UV-related damage(2017)
Authors: Jan Balzarini, Sandra Liekens
Pages: 760 - 769 - Antiviral and cytostatic evaluation of 5-(1-halo-2-sulfonylvinyl)- and 5-(2-furyl)uracil nucleosides(2017)
Authors: Robert Snoeck, Graciela Andrei, Sandra Liekens
Patents
1 - 2 of 2
- Novel anti-cancer thiophene compounds (Inventor)
- Anti-cancer compounds (Inventor)