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Researcher
Peter de Witte
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Molecular Biodiscovery (Division)
Responsible
From1 Apr 2013 → Today - Molecular Biodiscovery (Division)
Member
From1 Apr 2013 → Today
Projects
1 - 10 of 31
- PHGDH-ASM: Phosphoglycerate dehydrogenase (PHGDH) activators as novel antiseizure medications (ASM) with dual mode of actionFrom1 Oct 2022 → TodayFunding: IOF - technology validation in lab
- Excitation-inhibition imbalance in autism-epilepsy comorbidity, a preclinical and clinical studyFrom1 Oct 2021 → 30 Sep 2023Funding: BOF - projects
- Development of innovative multi-dimensional liquid chromatography methods for the analysis of organic micropollutants and their degradation products in environmental waterFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Therapeutic strategies for Dravet syndrome: upregulation of endogenous SCN1A and modulation of remodelingFrom1 Jun 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Multi-dimensional liquid chromatography for the analysis of complex samples.From1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- SmartDetox - Removal of organic micropollutants from waterFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Unraveling the in vivo host cell tropism and virus dissemination strategies of human norovirus.From28 Sep 2020 → TodayFunding: FWO fellowships
- A Lattice Light Sheet microscope to image subcellular molecular dynamics, cellular forces, neuroimmune interactions and neuronal activity in 3DFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Toxicity assessment of degradation products using zebrafish and advanced LC-MS techniquesFrom6 Jan 2020 → 6 Jan 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- An antisense strategy and network pharmacology approach in zebrafish models to identify novel targets for pharmacoresistant epilepsyFrom1 Nov 2019 → 30 Sep 2023Funding: FWO Strategic Basic Research Grant
Publications
121 - 130 of 146
- Role of autophagy pathways in PDT, a ROS-based anti-cancer therapy(2011)
Authors: Michael Dewaele, Patrizia Agostinis, Peter de Witte
Number of pages: 126 - Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage(2011)
Authors: Michael Dewaele, Noemí Rubio Romero, Tom Verfaillie, Peter de Witte, Patrizia Agostinis
Pages: 1402 - 1414 - Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versus urothelial cell carcinoma spheroids(2011)
Authors: Ben Van Cleynenbreugel, Evelyne Lerut, Hendrik Van Poppel, Peter de Witte
Pages: 151 - 159 - Zebrafish-based identification and characterization of bioactive stevia metabolites and steviol derivatives(2011)
Authors: Peter de Witte, Wim De Borggraeve, Wim Dehaen
Pages: 146 - 146Number of pages: 1 - The role of zebrafish in the future of natural product discovery(2011)
Authors: Alex Crawford, Camila Esguerra, Peter de Witte
Pages: 137 - 146Number of pages: 10 - Little fish, big waves: The potential of zebrafish toxicity assays for high-throughput, in vivo drug safely screening(2010)
Authors: Peter de Witte, Camila Esguerra
Pages: 6 - 9 - Prevention of tumor cell reimplantation during transurethral resection: the in-vitro antiadhesive and cytotoxic properties of an irrigant containing polyethylene glycol 400(2010)
Authors: Ben Van Cleynenbreugel, Hendrik Van Poppel, Peter de Witte
Pages: 645 - 650 - In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin(2010)
Authors: Peter de Witte
Pages: 178 - 185 - An improved orthotopic rat bladder tumor model using Dil-loaded fluorescent AY-27 cells(2010)
Authors: Ben Van Cleynenbreugel, Hendrik Van Poppel, Evelyne Lerut, Patrizia Agostinis, Peter de Witte
Pages: 986 - 993 - Topical treatment of disseminated superficial actinic porokeratosis with hypericin-photodynamic therapy: A case report(2010)
Authors: Peter de Witte, Rik Roelandts
Pages: 123 - 125
Patents
1 - 10 of 10
- Treatment of pharmacoresistant epilepsy (Inventor)
- Idebenone in the treatment of drug resistant epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Anticonvulsant activity of bisabolene sesquiterpenoids isolated from turmeric oil (Inventor)
- Anticonvulsant activity of turmeric oil and bisabolene sesquiterpenoids (Inventor)