Researcher
Franki Speleman
- Disciplines:Cell signalling, Cellular interactions and extracellular matrix, Cytoskeleton, Epigenetics, Cell death, Cell division, Cell growth and development, Cell movement, Transcription and translation, Medical epigenomics, Medical metagenomics, Medical genomics, Genetics, Molecular and cell biology not elsewhere classified, Intracellular compartments and transport, Membrane structure and transport, Posttranslational modifications, Stem cell biology, Structural biology, Immunogenetics, Clinical genetics and molecular diagnostics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
1 - 10 of 44
- Validation of Actionable Genomic ABerrations in a paediatric Oncology Network for Doctorate studentsFrom1 May 2024 → TodayFunding: BOF - doctoral mandates
- Spatial-omics deciphering of cellular and molecular responses to enhanced MYCN/ATR-CHK1 synthetic lethality in high-risk neuroblastomaFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Incucyte S3: Comprehensive cellular phenotyping using high-throughput live cell imagingFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapiesFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomicsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)From1 Jan 2022 → TodayFunding: BOF - projects
- Scrutinizing selective Aurora Kinase A inhibition as a novel entry point for synthetic lethality in neuroblastomaFrom1 Nov 2021 → TodayFunding: FWO fellowships
- The role of the SOX11 lineage-dependency factor as epigenetic master regulator in neuroblastomaFrom1 Oct 2021 → TodayFunding: BOF - projects
- The role of BRIP1 in MYCN driven neuroblastoma formation: from mechanism to druggingFrom1 Jan 2021 → TodayFunding: FWO Humanitarian research project Stand up against Cancer
- Targeting the degradation of proteins involved in neuroblastoma with bivalent ligands.From1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
Publications
21 - 30 of 91
- Zebravis als in-vivo model voor de studie van acute lymfatische leukemie(2019)
Authors: Siebe Loontiens, Suzanne Vanhauwaert, Lisa Depestel, Kaat Durinck, Franki Speleman
Pages: 11 - 17 - Data Descriptor: Meta-mining of copy number profiles of high-risk neuroblastoma tumors(2018)
Authors: Pauline Depuydt, J Koster, V Boeva, TD Hocking, Franki Speleman, G Schleiermacher, Katleen De Preter
- A mechanistic classification of clinical phenotypes in neuroblastoma.(2018)
Authors: Sandra Ackermann, Maria Cartolano, Barbara Hero, Anne Welte, Yvonne Kahlert, Andrea Roderwieser, Christoph Bartenhagen, Esther Walter, Judith Gecht, Laura Kerschke, et al.
Pages: 1165 - 1170 - Promoter-associated proteins of EPAS1 identified by enChIP-MS : a putative role of HDX as a negative regulator(2018)
Authors: Arash Hamidian, Marica Vaapil, Kristoffer von Stedingk, Toshitsugu Fujita, Camilla U Persson, Pontus Eriksson, Srinivas Veerla, Katleen De Preter, Franki Speleman, Hodaka Fujii, et al.
Pages: 291 - 298 - LDHA in neuroblastoma is associated with poor outcome and its depletion decreases neuroblastoma growth independent of aerobic glycolysis(2018)
Authors: Carmen Dorneburg, Matthias Fischer, Thomas FE Barth, Wolfgang Mueller-Klieser, Barbara Hero, Judith Gecht, Daniel R Carter, Katleen De Preter, Benjamin Mayer, Lisa Christner, et al.
Pages: 5772 - 5783 - Epigenetic regulation of neuroblastoma development(2018)
Authors: Kaat Durinck, Franki Speleman
Pages: 309 - 324 - A mechanistic classification of clinical phenotypes in neuroblastoma(2018)Volume: 65
Authors: S Ackermann, M Cartolano, B Hero, A Roderwieser, C Bartenhagen, C Rosswog, F Hertwig, T Simon, A Eggert, Franki Speleman, et al.
Pages: S234 - S234 - LDHA predicts poor survival in neuroblastoma and its depletion causes aerobic glycolysis-independent inhibition of neuroblastoma cells(2018)Volume: 65
Authors: C Dorneburg, M Fischer, TFE Barth, W Mueller-Klieser, B Hero, J Gecht, DR Carter, Katleen De Preter, Franki Speleman, GM Marshall, et al.
Pages: S238 - S238 - Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma(2018)
Authors: Kristina B Emdal, Anna-Kathrine Pedersen, Dorte B Bekker-Jensen, Alicia Lundby, Shana Claeys, Katleen De Preter, Franki Speleman, Chiara Francavilla, Jesper V Olsen
- Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia(2018)
Authors: Elaine G Garcia, Sowmya Iyer, Sara P Garcia, Siebe Loontiens, Ruslan I Sadreyev, Franki Speleman, David M Langenau
Pages: 1860 - 1865
Patents
1 - 1 of 1