Researcher
Franki Speleman
- Disciplines:Cell signalling, Cellular interactions and extracellular matrix, Cytoskeleton, Epigenetics, Cell death, Cell division, Cell growth and development, Cell movement, Transcription and translation, Medical epigenomics, Medical metagenomics, Medical genomics, Genetics, Molecular and cell biology not elsewhere classified, Intracellular compartments and transport, Membrane structure and transport, Posttranslational modifications, Stem cell biology, Structural biology, Immunogenetics, Clinical genetics and molecular diagnostics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
31 - 40 of 44
- Longitudinal imaging of cellular dynamics with a biostation IM-Q (microscope with sensitive CCD camera and integrated incubator)From1 Jun 2015 → 31 May 2017Funding: BOF - Other initiatives
- Exploring the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia through zebrafish modelingFrom1 Jan 2015 → 31 Dec 2017Funding: Foundations, funds and other with scientific goal
- Zebrafish transgenic and patient xenograft transplantation models of pediatric tumors for the pre-clinical drug testingFrom1 Jan 2015 → 31 Dec 2017Funding: Foundations, funds and other with scientific goal
- Targeting the leukemic cancer stem cell in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL)From1 Jan 2015 → 31 Dec 2017Funding: Foundations, funds and other with scientific goal
- Dynamic interplay between DNA mehtylation, histone modifications and the activity of super enhancers in the pathogenesis of immature T-ALLFrom1 Jan 2015 → 31 Dec 2017Funding: Foundations, funds and other with scientific goal
- RUNX2 as a driver of poor prognostic early T-cell progenitor leukemiaFrom1 Mar 2014 → 28 Feb 2017Funding: Nonprofit institution or equivalents
- Improved outcome prediction of children with neuroblastoma using an integrated m/miRNA and DNA methylation signature (Stichting tegen Kanker)From1 Jan 2013 → 31 Dec 2022Funding: Foundations, funds and other with scientific goal
- IVIS Lumina II Bioluminescence camera for laboratory animal researchFrom15 Jun 2012 → 30 Jun 2016Funding: BOF - Other initiatives
- A DNA methylation signature as biomarker for prognosis in children with neuroblastomaFrom1 Mar 2011 → 31 Dec 2014Funding: Foundations, funds and other with scientific goal
- European Network for Cancer research in Children and Adolescents (ENCCA)From1 Jan 2011 → 31 Dec 2015Funding: Health
Publications
1 - 10 of 91
- MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression(2024)
Authors: Alice Salib, Nisitha Jayatilleke, Janith A. Seneviratne, Chelsea Mayoh, Katleen De Preter, Franki Speleman, Belamy B. Cheung, Daniel R. Carter, Glenn M. Marshall
Pages: 363 - 377 - HTSplotter : an end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening(2024)
Authors: Carolina de Carvalho Nunes, Jasper Anckaert, Fanny De Vloed, Jolien De Wyn, Kaat Durinck, Jo Vandesompele, Franki Speleman, Vanessa Vermeirssen
- Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma(2024)
Authors: Stéphane Van Haver, Yujie Fan, Sarah-Lee Bekaert, Celine Everaert, Wouter Van Loocke, Vittorio Zanzani, Joke Deschildre, Ines Fernandez Maestre, Adrianna Amaro, Vanessa Vermeirssen, et al.
- Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN(2024)
Authors: Jonatan Linus Gabre, Peter Merseburger, Arne Claeys, Joachim Siaw, Sarah-Lee Bekaert, Franki Speleman, Bengt Hallberg, Ruth H Palmer, Jimmy Van den Eynden
- Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma(2023)
Authors: Jill Deleu, Hanne Van Droogenbroeck, Jasper Anckaert, Anneleen Decock, Jilke De Wilde, Kaat Durinck, Liselot Mus, Justine Nuytens, Muhammad Rishfi, Kathleen Schoofs, et al.
- Mitotic dysregulation at tumor initiation creates a therapeutic vulnerability to combination anti-mitotic and pro-apoptotic agents for MYCN-driven neuroblastoma(2023)
Authors: Lei Zhai, Anushree Balachandran, Rebecca Larkin, Janith A. Seneviratne, Sylvia A. Chung, Amit Lalwani, Shoma Tsubota, Dominik Beck, Kenji Kadomatsu, Anneleen Beckers, et al.
- Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma(2023)
Authors: Jordan F. Hastings, Sharissa L. Latham, Alvin Kamili, Madeleine S. Wheatley, Jeremy Z. R. Han, Marie Wong-Erasmus, Monica Phimmachanh, Max Nobis, Chiara Pantarelli, Antonia L. Cadell, et al.
- Longitudinal evaluation of serum microRNAs as biomarkers for neuroblastoma burden and therapeutic p53 reactivation(2023)
Authors: Alan Van Goethem, Jill Deleu, Nurten Yigit, Celine Everaert, Myrthala Moreno-Smith, Sanjeev A Vasudevan, Fjoralba Zeka, Eveline Barbieri, Franki Speleman, Pieter Mestdagh, et al.
- Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA(2022)
Authors: Vanessa Vermeirssen, Jill Deleu, Annelien Morlion, Celine Everaert, Jilke De Wilde, Jasper Anckaert, Kaat Durinck, Justine Nuytens, Muhammad Rishfi, Franki Speleman, et al.
- RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition(2022)
Authors: Carolina de Carvalho Nunes, Lisa Depestel, Liselot Mus, Kaylee M. Keller, Louis Delhaye, Amber Louwagie, Muhammad Rishfi, Alex Whale, Neesha Kara, Simon R. Andrews, et al.
Patents
1 - 1 of 1