Researcher
Franki Speleman
- Disciplines:Cell signalling, Cellular interactions and extracellular matrix, Cytoskeleton, Epigenetics, Cell death, Cell division, Cell growth and development, Cell movement, Transcription and translation, Medical epigenomics, Medical metagenomics, Medical genomics, Genetics, Molecular and cell biology not elsewhere classified, Intracellular compartments and transport, Membrane structure and transport, Posttranslational modifications, Stem cell biology, Structural biology, Immunogenetics, Clinical genetics and molecular diagnostics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
1 - 10 of 124
- Spatial-omics deciphering of cellular and molecular responses to enhanced MYCN/ATR-CHK1 synthetic lethality in high-risk neuroblastomaFrom1 Jan 2023 → TodayFunding: FWO research project
- Single-cell and spatial multi-omics exploration of tumor intrinsic and microenvironment responses to ALK-ATR-CHK1-RRM2 axis drugging in neuroblastomaFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Incucyte S3: Comprehensive cellular phenotyping using high-throughput live cell imagingFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Stichting tegen Kanker: "Agreement for the acquisition of an Advanced Technology Equipment Year 2022"From1 Jul 2022 → TodayFunding: Foundations, funds and other with scientific goal
- SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomicsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapiesFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Preclinical evaluation of combined RRM2/DNA damage response signaling as therapy for high-risk neuroblastomaFrom1 Feb 2022 → TodayFunding: Nonprofit institution or equivalents
- Replicatievork protectiefactoren als nieuwe doelwitten voor combinatietherapie en immunomodulering (REINFORCE)From1 Jan 2022 → 31 Dec 2022Funding: Nonprofit institution or equivalents
- Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)From1 Jan 2022 → TodayFunding: BOF - projects
- Scrutinizing selective Aurora Kinase A inhibition as a novel entry point for synthetic lethality in neuroblastomaFrom1 Nov 2021 → TodayFunding: FWO fellowships
Publications
1 - 10 of 402
- SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry(2023)
Authors: Bieke Decaesteker, Amber Louwagie, Siebe Loontiens, Fanny De Vloed, Sarah-Lee Bekaert, Juliette Roels, Suzanne Vanhauwaert, Sara De Brouwer, Ellen Sanders, A Berezovskaya, et al.
- Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma(2023)
Authors: Jordan F. Hastings, Sharissa L. Latham, Alvin Kamili, Madeleine S. Wheatley, Jeremy Z. R. Han, Marie Wong-Erasmus, Monica Phimmachanh, Max Nobis, Chiara Pantarelli, Antonia L. Cadell, et al.
- Longitudinal evaluation of serum microRNAs as biomarkers for neuroblastoma burden and therapeutic p53 reactivation(2023)
Authors: Alan Van Goethem, Jill Deleu, Nurten Yigit, Celine Everaert, Myrthala Moreno-Smith, Sanjeev A Vasudevan, Fjoralba Zeka, Fleur Demuynck, Eveline Barbieri, Franki Speleman, et al.
- The feasibility of using liquid biopsies as a complementary assay for copy number aberration profiling in routinely collected paediatric cancer patient samples(2022)
Authors: Ruben Van Paemel, Charlotte Vandeputte, Lennart Raman, Jolien Van Thorre, Leen Willems, Jo Van Dorpe, Malaïka Van der Linden, Jilke De Wilde, Andries De Koker, Björn Menten, et al.
Pages: 12 - 23 - Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA(2022)
Authors: Vanessa Vermeirssen, Jill Deleu, Annelien Morlion, Celine Everaert, Jilke De Wilde, Jasper Anckaert, Kaat Durinck, Justine Nuytens, Muhammad Rishfi, Franki Speleman, et al.
- RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition(2022)
Authors: Carolina de Carvalho Nunes, Lisa Depestel, Liselot Mus, Kaylee M. Keller, Louis Delhaye, Amber Louwagie, Muhammad Rishfi, Alex Whale, Neesha Kara, Simon R. Andrews, et al.
- Cellular senescence in neuroblastoma(2022)
Authors: Sofia Zanotti, Bieke Decaesteker, Suzanne Vanhauwaert, Bram De Wilde, Winnok De Vos, Franki Speleman
Pages: 1529 - 1538 - Complementarity of single-nucleus and single-cell RNA sequencing to study the transcriptional heterogeneity of neuroblastoma tumors(2022)
Authors: Noah Bonine, Tinne Thoné, Bavo Vanneste, Liselot Mus, Celine Everaert, Bram De Wilde, Franki Speleman, Charlotte Scott, Katleen De Preter
Number of pages: 1 - Complementarity of single-nucleus and single-cell RNA sequencing to study the transcriptional heterogeneity of neuroblastoma tumors(2022)
Authors: Noah Bonine, Tinne Thoné, Bavo Vanneste, Liselot Mus, Celine Everaert, Bram De Wilde, Franki Speleman, Charlotte Scott, Katleen De Preter
Number of pages: 1 - MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells(2021)
Authors: Sofia Zanotti, Suzanne Vanhauwaert, Christophe Van Neste, Volodimir Olexiouk, Jolien Van Laere, Marlies Verschuuren, Joni Van der Meulen, Liselot Mus, Kaat Durinck, Laurentijn Tilleman, et al.
Patents
1 - 1 of 1