Researcher
Bruno De Geest
- Keywords:immunology, polymer chemistry, Nanomedicine
- Disciplines:Biopharmaceutics, Adaptive immunology, Cancer therapy, Innate immunity, Synthesis of materials, Chemistry of clusters, colloids and nanomaterials, Macromolecular and materials chemistry not elsewhere classified, Animal immunology, Vaccines, Vaccinology
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Oct 2003 → Today
Projects
11 - 20 of 63
- A novel CRISPR/Cas9-based nanomedicine strategy targeting CD4+ cells to cure HIVFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- A novel CRISPR/Cas9-based nanomedicine strategy targeting CD4+ cells to cure HIVFrom1 Oct 2022 → 31 Oct 2022Funding: BOF - doctoral mandates
- Non-covalent hapten-immunogen next generation anti-opioid nanovaccinesFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- MATRACs / Membrane Anchoring Trafficking ChimerasFrom1 Oct 2022 → 31 Oct 2023Funding: BOF - doctoral mandates
- A targeted nanomedicine strategy for in vivo CD8+ T cell engineeringFrom1 Oct 2021 → 31 Oct 2022Funding: BOF - doctoral mandates
- Normalising tumour pH to bring the STING back in anti-tumour immunityFrom1 Oct 2021 → TodayFunding: FWO junior postdoctoral fellowship
- An innovative class of ionizable lipids for use in lipid nanoparticle based RNA therapeutics and vaccinesFrom15 Jul 2021 → 14 Jul 2022Funding: IOF - technology concept exploration
- JAMs - Janus Antibody-recruiting MacromoleculesFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Cut-and-paste chemistry: from circular plastics to immunotherapeuticsFrom1 Jan 2021 → TodayFunding: BOF - projects
- Multi-mode plate reader.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
Publications
1 - 10 of 213
- Towards a rational design of antibody‐recruiting molecules through a computational microscopy view of their interactions with the target antibody(2023)
Authors: Annemiek Uvyn, Corentin Tonneaux, Mathieu Fossépré, Aude Ouvrier‐Buffet, Bruno De Geest, Mathieu Surin
- Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids(2023)
Authors: Alexander Lamoot, Joris Lammens, Emily De Lombaerde, Zifu Zhong, Mark Gontsarik, Yong Chen, Thomas De Beer, Bruno De Geest
Pages: 4327 - 4334 - Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue(2023)
Authors: Zifu Zhong, Yong Chen, Kim Deswarte, Heleen Lauwers, Emily De Lombaerde, Xiaole Cui, Simon Van Herck, Tingting Ye, Mark Gontsarik, Stefan Lienenklaus, et al.
- A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment(2023)
Authors: Elly De Vlieghere, Koen Van de Vijver, Eva Blondeel, Nathan Carpentier, Rouba Ghobeira, Jarne Pauwels, Sebastian Riemann, Manon Minsart, Charlotte Fieuws, Johanna Mestach, et al.
- Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions(2023)
Authors: Helena Braet, Peter-Paul Fransen, Yong Chen, Simon Van Herck, Remco Mariën, Valérie Vanhoorne, Wim Ceelen, Annemieke Madder, Steven Ballet, Richard Hoogenboom, et al.
Pages: 138 - 150 - Sequence-defined antibody-recruiting macromolecules(2023)
Authors: Resat Aksakal, Corentin Tonneaux, Annemiek Uvyn, Mathieu Fossépré, Hatice Turgut, Nezha Badi, Mathieu Surin, Bruno De Geest, Filip Du Prez
Pages: 6572 - 6578 - Hapten/myristoyl functionalized poly(propyleneimine) dendrimers as potent cell surface recruiters of antibodies for mediating innate immune killing(2023)
Authors: Annemiek Uvyn, Marle Elisabeth Jacqueline Vleugels, Bas de Waal, Ahmed Emad Ibrahim Hamouda, Shikha Dhiman, Benoit Louage, Lorenzo Albertazzi, Damya Laoui, E. W. Meijer, Bruno De Geest
- pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages(2022)
Authors: Leonard Kaps, Anne Huppertsberg, Niklas Choteschovsky, Adrian Klefenz, Feyza Durak, Babara Schrörs, Mustafa Diken, Emma Eichler, Sebastian Rosigkeit, Sascha Schmitt, et al.
- In situ tumor vaccination with calcium‐linked degradable coacervate nanocomplex co‐delivering photosensitizer and TLR7/8 agonist to trigger effective anti‐tumor immune responses(2022)
Authors: Yutong Liu, Hui Li, Huajun Zhao, Yanyun Hao, Simon Van Herck, Zejun Xu, Guan Wang, Xiao Wang, Xinke Zhang, Xiaoyan Ge, et al.
- An intelligent nanovehicle armed with multifunctional navigation for precise delivery of toll‐like receptor 7/8 agonist and immunogenic cell death amplifiers to eliminate solid tumors and trigger durable antitumor immunity(2022)
Authors: Yanyun Hao, Hui Li, Huajun Zhao, Yutong Liu, Xiaoyan Ge, Xia Li, Hongfei Chen, Ailu Yang, Jing Zou, Xue Li, et al.