Organisation
Liver Connexin and Pannexin Research Group
Research Group
The research topic of LCPR is the study of the use of connexins and pannexins as drug targets and biomarkers for the therapy and diagnosis of acute and chronic liver disease.
Projects
1 - 7 of 7
- H2020: Ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessmentFrom1 May 2021 → TodayFunding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing
- Cellular communication as target and biomarker in liver disease and toxicity: from basic research towards clinical applicationFrom1 Jan 2021 → TodayFunding: BOF - Methusalem
- Production of next generation modulators of pannexins and connexins as novel therapeutics in the treatment of inflammatory cardiovascular, hepatic and joint diseases.From1 Mar 2020 → TodayFunding: H2020-EU.1.2.- EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
- GEAR: Brussels Liver Research to Valorisation Alliance (B-Liver): Valorisation of VUB’s liver cell biology and toxicology expertise via a consortium focused on liver therapeutics, patient and consumer safety.From1 Jan 2020 → TodayFunding: IOF - technology concept exploration, IOF - mandates
- CONNECT-2-CLINIC: Connexin and pannexin peptidomimetics and nanobodies for the clinical treatment of liver disease.From1 Jan 2020 → 31 Dec 2021Funding: H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
- Connexin hemichannels and pannexin channels as mediators and in vitro indicators of drug-induced cholestatic liver injury.From1 Nov 2019 → 31 Oct 2023Funding: FWO fellowships
- Are connexins, pannexins and their (hemi)channels novel biomarkers and pharmacological targets in the prognosis and therapy of liver cancer? (Toekenning in het kader van bilaterale onderzoekssamenwerking met Brazilië)From1 Jan 2019 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
Publications
11 - 20 of 98
- Experimental models of liver fibrosis(2016)
Authors: Sara Crespo Yanguas, Bruno Cogliati, Joost Willebrords, Michael Maes, Isabelle Colle, Bert Van den Bossche, Claudia Pinto Marques Souza de Oliveira, Wellington Andraus, Venâncio Avancini Ferreira Alves, Isabelle Leclercq, et al.
Pages: 1025-1048 - Connexin32 deficiency exacerbates carbon tetrachloride-induced hepatocellular injury and liver fibrosis in mice.(2016)
Authors: Bruno Cogliati, Sara Crespo Yanguas, Thiago P.A. Aloia, Marina S. Nogueira, Lucas M. Chaible, Daniel S. Sanches, Joost Willebrords, Michael Maes, Isabel Veloso Alves Pereira, Inar A. de Castro, et al.
Pages: 362-370 - Astrocytic Connexin43 Channels as Candidate Targets in Epilepsy Treatment(2020)
Authors: Laura Walrave, Mathieu Vinken, Luc Leybaert, Ilse Smolders
- Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity(2017)
Authors: Michael Maes, Mitchell R. Mcgill, Tereza Cristina da Silva, Chloé Abels, Margitta Lebofsky, James L Weemhoff, Taynã Tiburcio, Isabel Veloso Alves Pereira, Joost Willebrords, Sara Crespo Yanguas, et al.
Pages: 2245-2261 - Alcohol intake and cancer risk, in: Nutrition and Cancer Prevention.(2019)
Authors: Mathieu Vinken
Pages: 108-127Number of pages: 19 - Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction(2016)
Authors: Danny Bavli, Sebastian Prill, Elishai Ezra, Gahl Levy, Merav Cohen, Mathieu Vinken, Jan Vanfleteren, Magnus Jaeger, Yaakov Nahmias
Pages: E2231-E2240 - What is understood by “animal-free research”?(2019)
Authors: Stina Oredsson, S. Coecke, J. van der Valk, Mathieu Vinken
Pages: 143-144 - Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis(2019)
Authors: Guilherme Ribeiro Romualdo, Ariane Bartolomeu Rocha, Mathieu Vinken, Bruno Cogliati, Fernando Salvador Moreno, María Angel García Chaves, Luis Fernando Barbisan
Pages: 567-589 - Mode-of-action working group: capturing mode-of-action knowledge(2015)Volume: 5
Authors: Brigitte Landesmann, Mathieu Vinken
Pages: 296-299 - New approach methodologies (NAMs) for human-relevant biokinetics predictions: meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment(2020)
Authors: Ans Punt, Hans Bouwmeester, Bas J. Blaauboer, Sandra Coecke, Betty Hakkert, Delilah Hendriks, Paul Jennings, Nynke Kramer, Sibylle Neuhoff, Roos Masereeuw, et al.
Pages: 607-622