Organisation
Experimental Cardiology
Division
Research focuses on molecular mechanisms of excitation-contraction coupling in cardiac myocytes (electrophysiology, advanced calcium imaging), cellular remodeling in cardiac disease: ischemia and heart failure, mechanisms of arrhythmias. Research further aims to understand epigenetic mechanisms of adaptive and maladaptive remodeling of cardiac myocytes. Other work focuses on molecular pathways in metabolic cardiovascular diseases and biomarkers.
Current researchers
1 - 10 of 17 results
- H Llewelyn Roderick (Responsible)
- Matthew Amoni (Member)
- Konstantinos Chatzieleftheriadis (Member)
- Joshua Jeen Tung Chung (Member)
- Fiona DE MATOS (Member)
- Rosa Donate Puertas (Member)
- Eef Dries (Member)
- Samaneh Ekhteraeitousi (Member)
- David Fajardo (Member)
- Yile Fu (Member)
Projects
1 - 10 of 54
- Deciphering Molecular Pathways of Hypoxia Sensitivity in Adult Cardiomyocytes: An Integrative Cross-Species InvestigationFrom1 Apr 2024 → TodayFunding: Other federal public and semi-governmental institutions
- Human Stem Cell-Derived Cardiac Models to Investigate Cell-Cell Interactions in Epicardial Activation and Cardiac RemodelingFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel ex vivo approach to study local Ca2+-induced triggered activities in ventricular arrhythmias using living adult cardiac slicesFrom1 Sep 2023 → TodayFunding: BOF - tenure track
- Connexin-43 Hemichannels as pro-arythmic mediators in Cardiac Hypertrophy and Heart FailureFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding how neutrophil extracellular traps (NETs) contribute to vulnerability of the ageing heartFrom1 Oct 2022 → TodayFunding: FWO fellowships
- Investigating the role of DNA methylation in the failing and in the ageing heartFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Subcellular Ca2+ signalling microdomains regulating cardiomyocyte growth and functionsFrom19 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Interventional X-ray system equipped with 3D rotational angiography for cardiovascular research in preclinical large animal models.From1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Spatially-Organized 3D Human Cardiac Bilayer Models for Duchenne Cardiomyopathy Modelling and Drug DiscoveryFrom23 Nov 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Cell-cell interactions and the role of tissue microarchitecture in cardiac arrhythmias after myocardial infarctionFrom15 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
301 - 310 of 367
- Differential sensitivity of Ca2+wave and Ca2+spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes(2010)
Authors: Niall Macquaide
Pages: 4731 - 4742 - Mixed Signals: Interaction between RyR and IP3R Mediated Calcium Release Shapes the Calcium Transient for Hypertrophic Signalling in Cardiomyocytes(2018)
Authors: Hilary Hunt, Gregory Bass, H Llewelyn Roderick, Christian Soeller, Vijay Rajagopal, Edmund Crampin
Pages: 212A - 213A - An update on nuclear calcium signalling(2009)
Authors: Martin D Bootman, Claire Fearnley, Ioannis Smyrnias, Fraser MacDonald, H Llewelyn Roderick
Pages: 2337 - 2350 - Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation(2009)
Authors: Ronald Driesen
Pages: 19 - 27 - Structural and Functional Remodeling of the Coupling between Sarcolemmal Ca2+ Channels and the Ryanodine Receptor in Atrial Fibrillation(2008)
Authors: Ilse Lenaerts, Virginie Bito, Patricia Holemans, Hein Heidbuchel, Karin Sipido, Rik Willems
Pages: S346 - S346 - Subcellular calcium dynamics in a whole-cell model of an atrial myocyte(2012)
Authors: H Llewelyn Roderick
Pages: 2150 - 2155 - 2D+T Imaging of Calcium Signaling Microdomains in Cardiac Myocytes(2019)
Authors: Mouna Abdesselem, Guillaume Gilbert, H Llewellyn Roderick, Karin R Sipido
Pages: 43A - 43A - Dynamic imaging of calcium and STIM1 in the same cell using wide-field and TIRF microscopy(2008)
Authors: H Llewelyn Roderick
Pages: 347 - 348 - Compensatory and decompensatory alterations in cardiomyocyte Ca2+ dynamics in hearts with diastolic dysfunction following aortic banding(2017)
Authors: Sara Gattoni, Asmund Treu Roe, Jan Magnus Aronsen, Ivar Sjaastad, William E Louch, Nicolas P Smith, Steven A Niederer
Pages: 3867 - 3889 - Role of nitric oxide and oxidative stress in a sheep model of persistent atrial fibrillation (vol 15, pg 754, 2013)(2013)
Authors: Ilse Lenaerts, Ronald B Driesen, Nerea Hermida, Patricia Holemans, Hein Heidbuechel, Stefan Janssens, Jean-Luc Balligand, Karin Sipido, Rik Willems
Pages: 1684 - 1684