Organisation
Experimental Cardiology
Division
Research focuses on molecular mechanisms of excitation-contraction coupling in cardiac myocytes (electrophysiology, advanced calcium imaging), cellular remodeling in cardiac disease: ischemia and heart failure, mechanisms of arrhythmias. Research further aims to understand epigenetic mechanisms of adaptive and maladaptive remodeling of cardiac myocytes. Other work focuses on molecular pathways in metabolic cardiovascular diseases and biomarkers.
Current researchers
1 - 10 of 17 results
- H Llewelyn Roderick (Responsible)
- Matthew Amoni (Member)
- Konstantinos Chatzieleftheriadis (Member)
- Joshua Jeen Tung Chung (Member)
- Fiona DE MATOS (Member)
- Rosa Donate Puertas (Member)
- Eef Dries (Member)
- Samaneh Ekhteraeitousi (Member)
- David Fajardo (Member)
- Yile Fu (Member)
Projects
1 - 10 of 54
- Deciphering Molecular Pathways of Hypoxia Sensitivity in Adult Cardiomyocytes: An Integrative Cross-Species InvestigationFrom1 Apr 2024 → TodayFunding: Other federal public and semi-governmental institutions
- Human Stem Cell-Derived Cardiac Models to Investigate Cell-Cell Interactions in Epicardial Activation and Cardiac RemodelingFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel ex vivo approach to study local Ca2+-induced triggered activities in ventricular arrhythmias using living adult cardiac slicesFrom1 Sep 2023 → TodayFunding: BOF - tenure track
- Connexin-43 Hemichannels as pro-arythmic mediators in Cardiac Hypertrophy and Heart FailureFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding how neutrophil extracellular traps (NETs) contribute to vulnerability of the ageing heartFrom1 Oct 2022 → TodayFunding: FWO fellowships
- Investigating the role of DNA methylation in the failing and in the ageing heartFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Subcellular Ca2+ signalling microdomains regulating cardiomyocyte growth and functionsFrom19 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Interventional X-ray system equipped with 3D rotational angiography for cardiovascular research in preclinical large animal models.From1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Spatially-Organized 3D Human Cardiac Bilayer Models for Duchenne Cardiomyopathy Modelling and Drug DiscoveryFrom23 Nov 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Cell-cell interactions and the role of tissue microarchitecture in cardiac arrhythmias after myocardial infarctionFrom15 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
291 - 300 of 367
- RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes(2021)
Authors: Geert Bultynck, Maarten De Smet
Pages: 123 - 136 - Luminal short-chain fatty acids and 5-HT acutely activate myenteric neurons in the mouse proximal colon(2021)
Authors: Candice Fung, Bert Cools, Tobie Martens, Jan Tack, Youcef Kazwiny, Pieter Vanden Berghe
- Discrete sites of frequent premature ventricular complexes cluster within the infarct border zone and coincide with high frequency of delayed afterdepolarizations under adrenergic stimulation(2021)
Authors: Matthew Amoni, Piet Claus, Eef Dries, Stijn De Buck, Bert Vandenberk, Sebastian Ingelaere, Dylan Vermoortele, H Llewelyn Roderick, Karin Sipido, Rik Willems
Pages: 1976 - 1987 - Inhalation/Exhalation Ratio Modulates the Effect of Slow Breathing on Heart Rate Variability and Relaxation(2014)
Authors: Ilse Van Diest, André Aubert, Devy Widjaja, Deb Vansteenwegen, Elke Vlemincx
Pages: 171 - 180 - DEG (differentially expressed gene) or not DEG that is the question: Should we compare between datasets or not?(2023)
Authors: H Llewelyn Roderick
- Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells(2017)
Authors: Alicia Sanchez Linde, Kateryna Demydenko, Yeranddy Aguiar Alpizar, Julio Alvarez Collazo, Stevan Čokić, Peter Hoet, Karel Talavera Pérez
Pages: 43 - ER Ca2+ release and store-operated Ca2+ entry – partners in crime or independent actors in oncogenic transformation?(2019)
Authors: Flore Sneyers, Geert Bultynck, H Llewelyn Roderick
- Atrial remodeling during persistent atrial fibrillation: focus on nitric oxide and calcium homeostasis(2011)
Authors: Ilse Lenaerts, Rik Willems, Karin Sipido, Stefan Janssens
Number of pages: 126 - Intracellular Calcium Signalling(2009)
Authors: D Harzheim, H Llewelyn Roderick, MD Bootman
Pages: 937 - 942 - The use of living myocardial slices as a novel disease model to study cardiac arrhythmogenicity in vitro(2020)
Authors: Ifigeneia Bardi, Eef Dries, Raquel Nunez-Toldra, Fotios Pitoulis, Carolyn Carr, Cesare M Terracciano
Pages: 49 - 50