Publicaties
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KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation Universiteit Gent
KLHL12 promotes non-lysine ubiquitination of the dopamine receptors D-4.2 and D-4.4, but not of the ADHD-associated D-4.7 variant Universiteit Gent
KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation Vrije Universiteit Brussel
In previous studies, we identified KLHL12 as a novel interaction partner of the dopamine D4 receptor that functions as an adaptor in a Cul3-based E3 ubiquitin ligase complex to target the receptor for ubiquitination. In this study, we show that KLHL12 promotes poly-ubiquitination of the receptor by performing ubiquitination assays in eukaryotic cells. Furthermore, we demonstrate that KLHL12 not only interacts with both immature, ER-associated ...
RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma Vrije Universiteit Brussel
The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination Universiteit Gent
Ubiquitination controls and fine-tunes many signaling processes driving immunity, inflammation, and cancer. The E3 ubiquitin ligase HOIL-1 (heme-oxidized IRP2 ubiquitin ligase-1) is increasingly implicated in different signaling pathways and plays a vital role in immune regulation. HOIL-1 co operates with the E3 ubiquitin ligase HOIP (HOIL-1 interacting protein) to modify specific nuclear factor-B (NF-B) signaling proteins with linear M1-linked ...
A COFRADIC protocol to study protein ubiquitination Universiteit Gent
Ubiquitination of Listeria virulence factor InlC contributes to the host response to infection Universiteit Gent
Non-degradative and non-lysine mediated ubiquitination of the dopamine D4 receptor Universiteit Gent
A dynamic ubiquitination balance of cell proliferation and endoreduplication regulators determines plant organ size Universiteit Gent
Ubiquitination plays a crucial role throughout plant growth and development. The E3 ligase DA2 has been reported to activate the peptidase DA1 by ubiquitination, hereby limiting cell proliferation. However, the molecular mechanisms that regulate DA2 remain elusive. Here, we demonstrate that DA2 has a very high turnover and auto-ubiquitinates with K48-linkage polyubiquitin chains, which is counteracted by two deubiquitinating enzymes, ...