SARBECOVIRUS BINDERS Vlaams Instituut voor Biotechnologie
Xavier Saelens, Nico Callewaert, Bert Schepens, Kenny Roose, Han Remaut, Wim Nerinckx, Iebe Rossey, Koen Sedeyn, Loes van Schie, Dirk Reiter, Hannah Eeckhaut, Sieglinde De Cae
The invention relates to agents binding to sarbecoviruses of multiple clades and potently neutralizing sarbecovirus infection, in particular neutralizing SARS-CoV-1 and SARS-CoV-2 infection. The agents bind to a unique epitope of the sarbecovirus ACE2-receptor binding domain (RBD) but do not inhibit binding of ACE2 with the RBD. Application and uses of these agents are further part of this invention.