Refining wet lab experiments with in silico searches: A rational quest for diagnostic peptides in visceral leishmaniasis Universiteit Antwerpen
In silico regenerative medicine: how computational tools allow regulatory and financial challenges to be addressed in a volatile market KU Leuven
Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges KU Leuven
Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approach Vrije Universiteit Brussel
A previously published fragmentation method for making reliable negative in silico predictions has been applied to the problem of predicting skin sensitisation in humans, making use of a dataset of over 2750 chemicals with publicly available skin sensitisation data from 18 in vivo assays. An assay hierarchy was designed to enable the classification of chemicals within this dataset as either sensitisers or non-sensitisers where data from more ...