Publicaties
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Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice Vrije Universiteit Brussel
Background Chronic liver injury triggers a progenitor cell repair response, and liver fibrosis occurs when repair becomes deregulated. Previously, we reported that reactivation of the hedgehog pathway promotes fibrogenic liver repair. Osteopontin (OPN) is a hedgehog-target, and a cytokine that is highly upregulated in fibrotic tissues, and regulates stem-cell fate. Thus, we hypothesised that OPN may modulate liver progenitor cell response, and ...
Role of BMP Signaling in Pancreatic Progenitor Differentiation from Human Embryonic Stem Cells Vrije Universiteit Brussel
Transplantation of pancreatic progenitors derived from human embryonic stem cells (hESCs) is a promising way to treat diabetes. Strategies to obtain the required cell mass would rely on the up scaling of current differentiation protocols, or the proliferation of committed progenitors. We aimed at finding conditions that maintain a proliferating pancreatic progenitor pool and we assessed the role of BMP4 signaling in this process. hESCs were ...
Diversity in striatal synaptic circuits arises from distinct embryonic progenitor pools in the ventral telencephalon Universiteit Antwerpen
Synaptic circuits in the brain are precisely organized, but the processes that govern this precision are poorly understood. Here, we explore how distinct embryonic neural progenitor pools in the lateral ganglionic eminence contribute to neuronal diversity and synaptic circuit connectivity in the mouse striatum. In utero labeling of T alpha 1-expressing apical intermediate progenitors (aIP), as well as other progenitors (OP), reveals that both ...
Pituitary Progenitor Cells Tracked Down by Side Population Dissection KU Leuven Universiteit Antwerpen
Sca1(high) subset within the SP, stem cell growth factors that induce SP expansion, affect transcription of embryonic factors, suggesting impact on a developmental program that unfolds within this SP compartment. Non-Sca1(high) SP cells, revealed by Sox2 expression, are observed in the postulated periluminal stem/progenitor cell niche, but also in small groups scattered over the gland, thereby advocating the existence of multiple niches. In ...
Microcarrier Screening and Evaluation for Dynamic Expansion of Human Periosteum-Derived Progenitor Cells in a Xenogeneic Free Medium KU Leuven
An increasing need toward a more efficient expansion of adherent progenitor cell types arises with the advancements of cell therapy. The use of a dynamic expansion instead of a static planar expansion could be one way to tackle the challenges of expanding adherent cells at a large scale. Microcarriers are often reported as a biomaterial for culturing cells in suspension. However, the type of microcarrier has an effect on the cell expansion. In ...
Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells KU Leuven
In humans, nephrogenesis is completed prenatally, with nephrons formed until 34 weeks of gestational age. We hypothesized that urine of preterm neonates born before the completion of nephrogenesis is a noninvasive source of highly potent stem/progenitor cells. To test this hypothesis, we collected freshly voided urine at day 1 after birth from neonates born at 31-36 weeks of gestational age and characterized isolated cells using a single-cell ...
The hydrodynamics of the supernova remnant Cassiopeia A. The influence of the progenitor evolution on the velocity structure and clumping KU Leuven
Aims. There are large differences in the proposed progenitor models for the Cas A Supernova remnant (SNR). One of these differences is the presence or absence of a Wolf-Rayet (WR) phase of the progenitor star. The mass loss history of the progenitor star strongly affects the shape of the SNR. In this paper we investigate whether the progenitor star of Cas A had a WR phase or not and how long it may have lasted. Methods. We performed ...
Isolation and characterization of a novel population of progenitor cells from unmanipulated rat liver KU Leuven
Widespread use of liver transplantation in the treatment of hepatic diseases is restricted by the limited availability of donated organs. One potential solution to this problem would be isolation and propagation of liver progenitor cells or stem cells. Here, we report on the isolation of a novel progenitor cell population from unmanipulated (that is, no prior exposure to chemicals and no injury) adult rat liver. Rat liver cells were cultured ...
Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling KU Leuven
BACKGROUND & AIMS: Primary liver cancers include hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (CCA) and combined HCC-CCA tumors (cHCC-CCA). It has been suggested, but not unequivocally proven, that hepatic progenitor cells (HPCs) can contribute to hepatocarcinogenesis. We aimed to determine whether HPCs contribute to HCC, cHCC-CCA or both types of tumors. METHODS: To trace progenitor cells during hepatocarcinogenesis, we ...