The role of the post-translational modification citrullination in type 1 diabetes KU Leuven
Type 1 diabetes (T1D) is an autoimmune disease in which the immune system destroys insulin-producing pancreatic beta-cells, leading to a lack of insulin. Recently, we and others provided evidence that citrullination plays a role in T1D by identifying citrullinated glucose-regulated protein 78 (GRP78) and glutamic acid decarboxylase 65kDa (GAD65) as autoantigens in murine and human T1D, respectively. Citrullination is a post-translational ...