Carbohydrate metabolism is perturbed in peroxisome deficient hepatocytes due to mitochondrial dysfunction, AMP activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) suppressio KU Leuven
Hepatic peroxisomes are essential for lipid conversions which include the formation of mature conjugated bile acids, the degradation of branched chain fatty acids and the synthesis of docosahexaenoic acid. Through unresolved mechanisms, deletion of functional peroxisomes from mouse hepatocytes (L-Pex5-/- mice) causes severe structural and functional abnormalities at the inner mitochondrial membrane. We now demonstrate that the peroxisomal and ...