Publicaties
Gekozen filters:
Gekozen filters:
Regenerative potential of platelet concentrates in periodontal surgery KU Leuven
Regeneration is an emerging field in medicine. Current regenerative methods in periodontics include the use of autografts, allografts, alloplasts, or xenografts and naturally derived synthetic membranes that are either bioresorbable or nonresorbable. In the last twenty years, platelet concentrates (PCs) have emerged as a potential regenerative method in Oral and Maxillofacial Surgery, used as a sole filling material or as scaffold. Its purpose ...
Dental tissue regeneration in children, Can we mimic nature? KU Leuven
The general aim of this PhD project was to bridge part of the gap between in vitro studies and the clinical application for dental tissue regeneration with the main use of a cell-free approach. This aim was approached systematically, on the one hand, through the study of two clinical models involving tissue repair and regeneration namely tooth autotransplantation (TAT) and regenerative endodontic treatment (RET). On the other hand, by exploring ...
The adjunctive use of host modulators in non-surgical periodontal therapy Universiteit Antwerpen Universiteit Gent
Background Considering the role of the inflammatory host response in the pathogenesis of periodontitis, different host modulators have been proposed to enhance the outcomes of non-surgical periodontal therapy (NSPT), but their efficacy has not been fully clarified. Objectives This systematic review investigated the efficacy of host modulators combined with NSPT in reducing probing pocket depth (PPD) in periodontitis patients. Materials and ...
Development of Inks for Tissue Engineering of the Dentoalveolar Region through Bioprinting KU Leuven
Oral health issues in the dentoalveolar region are considered to have a significant impact on the individual's quality of life. Consequently, a range of treatment options have been developed to address complications in this region. However, certain shortcomings of these treatments have resulted in the exploration of regenerative strategies and tissue engineering approaches aimed at reconstructing tissue structures in this region. Within the ...
Controlling oral biofilms through modulation of the commensal oral microbiota. An alternative for antiseptics? KU Leuven
Modulation of the commensal oral microbiota is a promising preventive or therapeutic strategy to battle the initiation and progression of biofilm-related oral pathologies such as periodontal diseases. Although established classical therapies, based on mechanical removal of dental plaque and sometimes supplemented with the use of antimicrobials, have proven clinical and microbiological benefits, their limitations justify the exploitation of ...
In Vivo Micro‐Computerized Tomography Tracking of Human Periodontal Ligament Stem Cells Labeled with Gold Nanocomplexes Universiteit Hasselt KU Leuven
Gold nanocomplexes have been proposed as contrast agents for computerized tomography (CT) and cell tracking, which is especially useful in stem cell therapy. However, their potential for long-term in vivo cell detection is still unknown. This study proposes an optimized approach to labeling human periodontal ligament stem cells (hPDLSCs) with gold nanocomplexes to evaluate their detection with micro-CT after transplantation at four different rat ...
A 5-year prospective study on regenerative periodontal therapy of infrabony defects using minimally invasive surgery and a collagen-enriched bovine-derived xenograft Vrije Universiteit Brussel Universiteit Gent
Aim: The primary objective of this study was (1) to evaluate the 5-year clinical outcome of regenerative periodontal therapy (RPT) using minimally invasive surgery and a collagen-enriched bovine-derived xenograft and (2) to identify predictors for clinical attachment level (CAL) gain and vertical radiographic bone (RB) gain. Materials and methods: Ninety-five non-smoking patients with ≤ 25% full-mouth plaque and bleeding presenting ≥ 6 months ...
Engineered scaffolds and cell-based therapy for periodontal regeneration KU Leuven
BACKGROUND: The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy. METHODS: A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal ...
IL-1ß favors osteoclastogenesis via supporting human periodontal ligament fibroblasts KU Leuven
The balance between bone formation and bone resorption in inflammatory diseases is often disturbed. Periodontitis, a chronic inflammation of the tooth gums, leads to unwanted bone loss as a response to inflammatory compounds such as interleukin-1ß (IL-1ß). This excessive bone loss reflects an increased osteoclast formation and activity. Osteoclast formation is a multistep process driven by osteoclastogenesis supporting cells such as periodontal ...