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Effect of receptor specificity of A/Hong Kong/1/68 (H3N2) influenza virus variants on replication and transmission in pigs Universiteit Gent
Emerging options for interfering with influenza virus entry and replication KU Leuven
Influenza viruses are highly contagious respiratory pathogens with considerable medical and socio-economical burden, whether in the context of the seasonal influenza epidemics or the unpredictable, yet potentially, severe pandemics. The current influenza vaccines require annual updating and provide only partial protection. Hence, antiviral drugs are an essential component in the prevention and treatment of influenza virus infections. At the ...
In Vitro Characterization of the Carbohydrate-Binding Agents HHA, GNA, and UDA as Inhibitors of Influenza A and B Virus Replication KU Leuven Universiteit Gent
Here, we report on the anti-influenza virus activity of the mannose-binding agents Hippeastrum hybrid agglutinin (HHA) and Galanthus nivalis agglutinin (GNA) and the (N-acetylglucosamine) n -specific Urtica dioica agglutinin (UDA). These carbohydrate-binding agents (CBA) strongly inhibited various influenza A(H1N1), A(H3N2), and B viruses in vitro, with 50% effective concentration values ranging from 0.016 to 83 nM, generating selectivity ...
Distinct effects of T-705 (favipiravir) and ribavirin on influenza virus replication and viral RNA synthesis KU Leuven
T-705 (favipiravir) is a new antiviral agent in advanced clinical development for influenza therapy. It is supposed to act as an alternative substrate for the viral polymerase, causing inhibition of viral RNA synthesis or virus mutagenesis. These mechanisms were also proposed for ribavirin, an established and broad antiviral drug that shares structural similarity with T-705. We here performed a comparative analysis of the effects of T-705 and ...
Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways KU Leuven
Influenza A virus (IAV) and influenza B virus (IBV) cause yearly epidemics with significant morbidity and mortality. When zoonotic IAVs enter the human population, the viral hemagglutinin (HA) requires adaptation to achieve sustained virus transmission. In contrast, IBV has been circulating in humans, its only host, for a long period of time. Whether this entailed adaptation of IBV HA to the human airways is unknown. To address this question, we ...
Antibodies directed towards neuraminidase restrict influenza virus replication in primary human bronchial epithelial cells. Vlaams Instituut voor Biotechnologie Universiteit Gent
Structures of influenza A virus RNA polymerase offer insight into viral genome replication. Vlaams Instituut voor Biotechnologie Vrije Universiteit Brussel
De rol van receptor tyrosine kinasen en geassocieerde gangliosiden in de replicatie van het influenza virus KU Leuven
Influenza infections produce significant medical and socio-economic burden. Every year, human influenza A and B viruses cause millions of cases of severe respiratory illness and death. Every so often, a pandemic arises when a zoonotic influenza A virus with sustained human transmissibility enters the human population. Antivirals are crucial for influenza treatment and prevention, especially in fragile populations such as elderly. At the moment, ...
4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1 KU Leuven
Itaconate derivates, as well as the naturally produced metabolite, have been proposed as antivirals against influenza virus. Here, the mechanism behind the antiviral effects of exogenous 4-octyl itaconate (4-OI), a derivative of itaconate, against the influenza A virus replication is demonstrated. The data indicate that 4-OI targets the cysteine at position 528 of the CRM1 protein, resulting in inhibition of the nuclear export of viral ...