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Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma. KU Leuven
BACKGROUND: Systemic therapy for metastatic clear cell sarcoma (CCS) bearing EWSR1-CREB1/ATF1 fusions remains an unmet clinical need in children, adolescents, and young adults. METHODS: To identify key signaling pathway vulnerabilities in CCS, a multi-pronged approach was taken: (i) genomic and transcriptomic landscape analysis, (ii) integrated chemical biology interrogations, (iii) development of CREB1/ATF1 inhibitors, and (iv) antibody-drug ...
Comparative genomics of Burkholderia multivorans, a ubiquitous pathogen with a highly conserved genomic structure Universiteit Gent
Genomic variation in next-generation sequencing data: from human Y chromosomal phylogeny to insect genomics KU Leuven
In the past decade next-generation sequencing (NGS) technologies have revolutionized the fields of molecular biology, genetics and genomics by enabling cost-effective and quick generation of DNA sequence data with exquisite accuracy and resolution. The technical strategy of the NGS technology is straightforward: the sequencing throughput is boosted by miniaturizing the sequencing chemical reactions such that millions of those reactions can take ...
InSilico DB genomic datasets hub: an efficient starting point for analysing genomewide studies in GenePattern, Integrative Genomics Viewer, and R/Bioconductor Vrije Universiteit Brussel
Genomics datasets are increasingly useful for gaining biomedical insights, with adoption in the clinic underway. However, multiple hurdles related to data management stand in the way of their efficient large-scale utilization. The solution proposed is a web-based data storage hub. Having clear focus, flexibility and adaptability, InSilico DB seamlessly connects genomics dataset repositories to state-of-the-art and free GUI and command-line data ...
InSilico DB genomic datasets hub: an efficient starting point for analyzing genome-wide studies in GenePattern, Integrative Genomics Viewer, and R/Bioconductor Vrije Universiteit Brussel
Genomics datasets are increasingly useful for gaining biomedical insights, with adoption in the clinic underway. However, multiple hurdles related to data management stand in the way of their efficient large-scale utilization. The solution proposed is a web-based data storage hub. Having clear focus, flexibility and adaptability, InSilico DB seamlessly connects genomics dataset repositories to state-of-the-art and free GUI and command-line data ...
Public health in the genomic era: will Public Health Genomics contribute to major changes in the prevention of common diseases? KU Leuven
The completion of the Human Genome Project triggered a whole new field of genomic research which is likely to lead to new opportunities for the promotion of population health. As a result, the distinction between genetic and environmental diseases has faded. Presently, genomics and knowledge deriving from systems biology, epigenomics, integrative genomics or genome-environmental interactions give a better insight on the pathophysiology of common ...
Classification of feline hypertrophic cardiomyopathy-associated gene variants according to the American College of Medical Genetics and Genomics guidelines Universiteit Gent
Introduction The correct labeling of a genetic variant as pathogenic is important as breeding decisions based on incorrect DNA tests can lead to the unwarranted exclusion of animals, potentially compromising the long-term health of a population. In human medicine, the American college of Medical Genetics (ACMG) guidelines provide a framework for variant classification. This study aims to apply these guidelines to six genetic variants associated ...
PotatoMASH : a low cost, genome-scanning marker system for use in potato genomics and genetics applications Universiteit Gent Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
We have developed PotatoMASH (Potato Multi-Allele Scanning Haplotags), a novel low-cost, genome-scanning marker platform. We designed a panel of 339 multi-allelic regions placed at 1 Mb intervals throughout the euchromatic portion of the genome. These regions were assayed using a multiplex amplicon sequencing approach, which allows for genotyping hundreds of plants at a cost of 5 EUR/sample. We applied PotatoMASH to a population of over 700 ...