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The Leuven late life depression (L3D) study: PET-MRI biomarkers of pathological brain ageing in late-life depression: study protocol KU Leuven
BACKGROUND: Major depressive disorders rank in the top ten causes of ill health in all but four countries worldwide and are the leading cause of years lived with disability in Europe (WHO). Recent research suggests that neurodegenerative pathology may contribute to the development of late-life depression (LLD) in a sub-group of patients and represent a target for prevention and early diagnosis. In parallel, electroconvulsive therapy (ECT), which ...
Disrupting the rhythm of depression using Mobile Cognitive Therapy for recurrent depression: randomized controlled trial design and protocol Universiteit Gent
Attentional bias training in depression: therapeutic effects depend on depression severity Universiteit Gent
Electrical Brain Imaging Reveals the Expression and Timing of Altered Error Monitoring Functions in Major Depression Vrije Universiteit Brussel
Major depressive disorder (MDD) is characterized by disturbances in affect, motivation, and cognitive control processes, including error detection. However, the expression and timing of the impairments during error monitoring remain unclear in MDD. The behavior and event-related brain responses (ERPs) of 20 patients with MDD were compared with those of 20 healthy controls (HCs), while they performed a Go/noGo task. Errors during this task were ...
Depression, trauma and mentalizing : no influence of depressive symptoms on spontaneous theory of mind in a subclinical sample Universiteit Gent
Electrical brain imaging reveals the expression and timing of altered error monitoring functions in major depression Universiteit Gent
Is the geriatric depression scale a reliable screening tool for depressive symptoms in elderly patients with cognitive impairment? Vrije Universiteit Brussel Universiteit Antwerpen Universiteit Gent
OBJECTIVE: To determine the reliability of the 30-item Geriatric Depression Scale (GDS-30) for the screening of depressive symptoms in dementia and mild cognitive impairment (MCI) using the Cornell Scale for Depression in Dementia (CSDD) as the 'gold standard'.
METHODS: Diagnosed according to strictly applied clinical diagnostic criteria, patients with MCI (n = 156) and probable Alzheimer's disease (AD) (n = 247) were included. GDS-30, ...
Are apathy and depressive symptoms related to vascular white matter lesions in severe late life depression? KU Leuven
OBJECTIVE: Apathy symptoms are defined as a lack of interest and motivation. Patients with late-life depression (LLD) also suffer from lack of interest and motivation and previous studies have linked apathy to vascular white matter hyperintensities (WMH) of the brain in depressed and nondepressed patients. The aim of this study was to investigate the relationship between apathy symptoms, depressive symptoms, and WMH in LLD. We hypothesize that ...