Publicaties
Kharasch-type cyclizations of 2-substituted indole derivatives surprisingly lead to spiroindoles Universiteit Gent
Post-Ugi Cyclizations Towards Polycyclic N-Heterocycles KU Leuven
Gold and Silver Catalyzed 7-endo-dig Cyclizations for the Synthesis of Oxazepines KU Leuven Universiteit Gent
I-2/K2S2O8-Promoted ring-opening cyclizations of benzothiazoles and 3-oxo-3-arylpropanenitriles KU Leuven
Stable Bromiranium Ion Salts as Reagents for Biomimetic Indole Terpenoid Cyclizations Vrije Universiteit Brussel
Indole terpene alkaloids are a diverse group of natural products and show significant biological activities. To enable their biomimetic synthesis, electrophilic bromocyclization of polyenyl indole derivatives could be achieved using sterically demanding bromiranium ion salts with the weakly coordinating counterion BArF - as reagent. Starting from polyenyl indole derivatives, the corresponding bromocyclization products have been obtained with ...
Homohalocyclization: Electrophilic Bromine-Induced Cyclizations of Cyclopropanes Vrije Universiteit Brussel
Diversity-oriented synthesis of β-lactams and γ-lactams via a post-Ugi nucleophilic cyclization: Lewis acids as regioselective switch KU Leuven
The Suzuki-Miyaura Cross-Coupling as a Versatile Tool for Peptide Diversification and Cyclization. IF 3.465 Vrije Universiteit Brussel Universiteit Antwerpen
The (site-selective) derivatization of amino acids and peptides represents an attractive field with potential applications in the establishment of structure-activity relationships and labeling of bioactive compounds. In this respect, bioorthogonal cross-coupling reactions provide valuable means for ready access to peptide analogues with diversified structure and function. Due to the complex and chiral nature of peptides, mild reaction ...