Publicaties
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Involvement of connexin43 in acetaminophen-induced liver injury Vrije Universiteit Brussel
Background and aims
Being goalkeepers of liver homeostasis, gap junctions are also involved in hepatotoxicity. However, their role in this process is ambiguous, as gap junctions can act as both targets and effectors of liver toxicity. This particularly holds true for drug-induced liver insults. In the present study, the involvement of connexin 26, connexin32 and connexin43, the building blocks of liver gap junctions, was ...
Being goalkeepers of liver homeostasis, gap junctions are also involved in hepatotoxicity. However, their role in this process is ambiguous, as gap junctions can act as both targets and effectors of liver toxicity. This particularly holds true for drug-induced liver insults. In the present study, the involvement of connexin 26, connexin32 and connexin43, the building blocks of liver gap junctions, was ...
Connexines in the horse heart Universiteit Gent
Cholestasis Differentially Affects Liver Connexins KU Leuven Vrije Universiteit Brussel
Connexins are goal keepers of tissue homeostasis, including in the liver. As a result, they are frequently involved in disease. The current study was set up to investigate the effects of cholestatic disease on the production of connexin26, connexin32 and connexin43 in the liver. For this purpose, bile duct ligation, a well-known trigger of cholestatic liver injury, was applied to mice. In parallel, human hepatoma HepaRG cell cultures were ...
Expression of connexins and pannexins in diseased human liver Vrije Universiteit Brussel
Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction activity is crucial for the maintenance of hepatic homeostasis, while connexin hemichannels become particularly active in liver disease, such as hepatitis, fibrosis, cholestasis or even hepatocellular carcinoma. Channels consisting of connexin-like proteins named pannexins have been ...
Roles of connexins and pannexins in digestive homeostasis Vrije Universiteit Brussel
Connexin proteins are abundantly present in the digestive system. They primarily form gap junctions, which control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions drive a plethora of gastrointestinal and hepatic functional features, including gastric and gut motility, gastric acid secretion, intestinal innate immune defense, xenobiotic biotransformation, glycogenolysis, bile secretion, ammonia ...
Connexins and pannexins in liver damage Vrije Universiteit Brussel
Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function, these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these in these deleterious events, connexins and pannexins could represent a set of ...
The role of connexins, pannexins and their channels in liver fibrosis. Vrije Universiteit Brussel
While connexin-based gap junctions have been historically considered as goal keepers of tissue physiology, connexin hemichannels and pannexin channels have lately gained considerable attention as drivers of pathological processes, including cell death and inflammation. The objective of this doctoral thesis project was to investigate the role of the latter 2 channel types, in particular hemichannels consisting of connexin32 (Cx32) and connexin43 ...
The role of connexins, pannexins and their channels in acute liver failure Vrije Universiteit Brussel
In the past few years, connexin hemichannels and pannexin channels have emerged as so-called pathological pores, since they drive a number of deleterious events, including cell death and inflammation. The objective of this doctoral thesis project was to investigate the role of both channel types, in particular hemichannels consisting of connexin32 (Cx32) and connexin43 (Cx43) as well as pannexin channels built up by pannexin1 (Panx1), in liver ...
Role of connexins, pannexins and their channels in liver cancer Vrije Universiteit Brussel
Direct intercellular communication mediated by connexin (Cx)-based gap junctions, consisting of 2 Cx hemichannels of adjacent cells, is a crucial goalkeeper of hepatic homeostasis. On the other hand, Cx hemichannels mediate paracrine communication, which has been implicated in various liver pathologies. Similarly, pannexin (Panx) channels have been identified as pathological pores.
The aim of this doctoral project was to characterize the ...
The aim of this doctoral project was to characterize the ...