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A gene expression based predictor for high risk myeloma treated with intensive therapy and autologous stem cell rescue Vrije Universiteit Brussel
Myeloma is characterized by a highly variable clinical outcome. Despite the effectiveness of high-dose therapy, 15% of patients relapse within 1 year. We show that these cases also have a significantly shorter post-relapse survival compared to the others (median 14.9 months vs. 40 months, p = 8.03 × 10(- 14)). There are no effective approaches to define this potentially distinct biological group such that treatment could be altered. In this ...
Gene and cell therapy for cystic fibrosis : from bench to bedside Universiteit Gent
Fetal stem cell transplantation and gene therapy KU Leuven
The present chapter summarizes our current knowledge on fetal stem cell and gene therapy. It focuses on these therapeutic alternatives in regard to past experiences and ongoing and planned studies in humans. Several methodological challenges are discussed that may have wide implications on how these methods could be introduced in clinical practices. Although still promising, the methods are afflicted with very special requirements not least in ...
Immunology of Gene and Cell Therapy KU Leuven
Development of Cell and Gene Therapy Products: Implementation of a Blended Learning Approach KU Leuven
In vitro modelling of local gene therapy with IL-15/IL-15Ra and a PD-L1 antagonist in melanoma reveals an interplay between NK cells and CD4+ T cells. Vlaams Instituut voor Biotechnologie Vrije Universiteit Brussel
In Utero Stem Cell and Gene Therapy: Current Status and Future Perspectives KU Leuven
Advances in prenatal diagnosis have led to the development of fetal therapies for congenital disorders. Although in utero surgical intervention has been used successfully for correction of anatomical defects that cause fetal demise or long-term disability, its clinical indications remain limited. In contrast, prenatal stem cell and gene therapy might have tremendous potential to treat multiple inherited disorders, and could dramatically expand ...
Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells. Vrije Universiteit Brussel
Effective gene therapy requires robust delivery of the desired genes into the relevant target cells, long-term gene expression, and minimal risks of secondary effects. The development of efficient and safe nonviral vectors would greatly facilitate clinical gene therapy studies. However, nonviral gene transfer approaches typically result in only limited stable gene transfer efficiencies in most primary cells. The use of nonviral gene delivery ...