Means and methods to treat inflammation Universiteit Gent
The present invention relates to a composition comprising MMP8 and TNFR1 inactivating antigen binding polypeptides, preferably antigen binding polypeptides comprising antibodies; it relates further to the use of such composition to treat inflammation, such as but not limited to systemic inflammatory response syndrome, sepsis, LPS induced inflammation, renal ischemia/reperfusion injury, ventilation induced lung injury, periodontal inflammation, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, ankylosing spondylitis, Lyme arthritis and osteoarthritis.