The intracerebral injection of Aβ1-42 oligomers does not invariably alter seizure susceptibility in mice Universiteit Antwerpen Vrije Universiteit Brussel
Objectives: Epileptiform activity and seizures are present in patients with Alzheimer's disease (AD) and genetic animal models of AD. Amyloid beta 1-42 (A beta(1-42)) oligomers are thought to be crucial in AD and can cause neuronal hyperexcitability in vitro. However, it is unclear whether these A beta(1-42) oligomers cause the increased seizure susceptibility in vivo in people with AD and in AD animal models, nor via which mechanisms it would ...