Publicaties
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ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms Universiteit Gent
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia Universiteit Gent
Oncogenic ZEB2 activation drives sensitivity towards LSD1 inhibition in T-Cell acute lymphoblastic leukemia Universiteit Gent
The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma Universiteit Gent
Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells. Vlaams Instituut voor Biotechnologie Universiteit Gent
Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons KU Leuven
Mammalian pallial (cortical and hippocampal) and striatal interneurons are both generated in the embryonic subpallium, including the medial ganglionic eminence (MGE). Herein we demonstrate that the Zfhx1b (Sip1, Zeb2) zinc finger homeobox gene is required in the MGE, directly downstream of Dlx1&2, to generate cortical interneurons that express Cxcr7, MafB, and cMaf. In its absence, Nkx2-1 expression is not repressed, and cells that ...