Vagus nerve stimulation suppresses pilocarpine-induced limbic seizures and increases hippocmapal extracellular noradrenalin concentration Vrije Universiteit Brussel
RATIONALE:
Vagus nerve stimulation (VNS) is an adjunctive treatment for patients with refractory epilepsy. Increased release of noradrenalin in the hippocampus, caused by altered activity in the locus coeruleus, has been advanced as a possible mechanism of action of VNS in epilepsy. The aim of this study was to simultaneously evaluate the effect of VNS on pilocarpine-induced limbic seizures and on hippocampal EC neurotransmitter ...
Vagus nerve stimulation (VNS) is an adjunctive treatment for patients with refractory epilepsy. Increased release of noradrenalin in the hippocampus, caused by altered activity in the locus coeruleus, has been advanced as a possible mechanism of action of VNS in epilepsy. The aim of this study was to simultaneously evaluate the effect of VNS on pilocarpine-induced limbic seizures and on hippocampal EC neurotransmitter ...